Key Specifications Table
|Species Reactivity||Key Applications||Host||Format||Antibody Type|
|R||IHC, IH(P), WB||Sh||Purified||Polyclonal Antibody|
|Presentation||Purified immunoglobulin. Lyophilized, no preservatives. Reconstitute with 500 μL of sterile distilled water (1 mg/mL).|
|Safety Information according to GHS|
|Material Size||500 µg|
|SHEEP ANTI-c-fos POLYCLONAL ANTIBODY - 2446719||2446719|
|SHEEP ANTI-c-fos POLYCLONAL ANTIBODY - 2458945||2458945|
|SHEEP ANTI-c-fos - 2147043||2147043|
|SHEEP ANTI-c-fos -2610483||2610483|
|SHEEP ANTI-c-fos -2624970||2624970|
|SHEEP ANTI-c-fos -2685235||2685235|
|SHEEP ANTI-c-fos -2712283||2712283|
|SHEEP ANTI-c-fos -2718323||2718323|
|SHEEP ANTI-c-fos -2726124||2726124|
|SHEEP ANTI-c-fos -2736451||2736451|
|SHEEP ANTI-c-fos -2739383||2739383|
|SHEEP ANTI-c-fos -2807021||2807021|
|SHEEP ANTI-c-fos POLYCLONAL ANTIBODY - 1984654||1984654|
|SHEEP ANTI-c-fos POLYCLONAL ANTIBODY - 2091720||2091720|
|SHEEP ANTI-c-fos POLYCLONAL ANTIBODY - 2287698||2287698|
|SHEEP ANTI-c-fos POLYCLONAL ANTIBODY - 2326293||2326293|
|SHEEP ANTI-c-fos POLYCLONAL ANTIBODY -2504796||2504796|
|Reference overview||Application||Pub Med ID|
|Inhibition of GSK3β improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome. |
Guo, W; Murthy, AC; Zhang, L; Johnson, EB; Schaller, EG; Allan, AM; Zhao, X
Human molecular genetics 21 681-91 2012
Fragile X syndrome (FXS), a common inherited form of intellectual disability with learning deficits, results from a loss of fragile X mental retardation protein (FMRP). Despite extensive research, treatment options for FXS remain limited. Since FMRP is known to play an important role in adult hippocampal neurogenesis and hippocampus-dependent learning and FMRP regulates the adult neural stem cell fate through the translational regulation of glycogen synthase kinase 3β (GSK3β), we investigated the effects of a GSK3β inhibitor, SB216763, on Fmr1 knockout mice (Fmr1 KO). We found that the inhibition of GSK3β could reverse the hippocampus-dependent learning deficits and rescue adult hippocampal neurogenesis at multiple stages in Fmr1 KO mice. Our results point to GSK3β inhibition as a potential treatment for the learning deficits seen in FXS.
|Changes in apoptosis-related protein (p53, Bax, Bcl-2 and Fos) expression with DNA fragmentation in the central nervous system in rats after closed head injury. |
J Lu, S Moochhala, C Kaur, E Ling
Neuroscience letters 290 89-92 2000
This study aimed to examine the temporal profile of neuronal apoptosis in the central nervous system (CNS) following closed head injury in rat. Fos immunoreactivity was detected in neuronal nuclei in the cerebral cortex at 2 h after head injury. At 4 h, Bax protein expression was elevated with a concomitant down-regulation of Bcl-2 expression. Along with this, a marked immunoexpression of p53 was also observed in these cells. Double immunolabelling study has shown the colocalization of Bax immunoreactivity with Bcl-2 and p53. In rats killed 1 day after injury, a variable number of transferase d-UTP nick-end labelling positive cells were observed. Present findings suggest that the upregulation of p53 and a shift in the ratio of Bcl-2 to Bax may contribute to neuronal apoptosis in the CNS after closed head injury.
|Disinhibition of the rostral ventral medulla increases blood pressure and Fos expression in bulbospinal neurons. |
Minson, J B, et al.
Brain Res., 646: 44-52 (1994) 1994
The GABA agonist muscimol, injected into the depressor area of the caudal ventrolateral medulla, increased blood pressure and increased the expression of the immediate early gene c-fos in the rostral ventral medulla (RVM) of the rat. The number of Fos-immunoreactive (Fos-IR) neurons seen in the RVM was increased 3-fold after muscimol compared to Fos-IR after vehicle treatment. In the rostral aspect of the RVM approximately half of the Fos-IR neurons were identified as spinally projecting after the injection of the retrograde tracer cholera toxin B subunit into the upper thoracic spinal cord. These bulbospinal Fos-IR neurons were identified in the lateral aspects of the RVM, in the area where baroreceptor-sensitive neurons have been identified in electrophysiological studies, and also in more medial areas of the RVM. Fos-IR neurons were also identified in the intermediolateral cell column of the thoracic spinal cord after muscimol injection, but were rarely observed in this area after vehicle treatment. This study demonstrates the functional connectivity of the caudal and rostral areas of the medulla oblongata and the spinal cord, supporting the view that the caudal ventrolateral medulla contains neurons that provide a tonic inhibitory control over neurons in the RVM and that, in turn, the spinally projecting neurons in the RVM provide an excitatory input to the spinal cord sympathetic preganglionic neurons.(ABSTRACT TRUNCATED AT 250 WORDS)
|Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein. |
van Straaten, F, et al.
Proc. Natl. Acad. Sci. U.S.A., 80: 3183-7 (1983) 1983
The complete nucleotide sequence of the c-fos(human) gene, the human cellular homolog of the oncogene (v-fos) of Finkel-Biskis-Jinkins murine osteosarcoma virus, has been determined. The c-fos(human) gene contains four discontinuous regions when compared with the v-fos gene. Three of the discontinuities are flanked by sequences characteristic of introns, while the fourth discontinuity is due to a deletion of 104 base pairs in the v-fos gene. As a consequence of the deletion, the predicted c-fos(human) and v-fos gene products differ at their carboxyl termini. Transcripts of 2.2 kilobases from the c-fos(human) gene have been identified in human cells. The sizes of these transcripts are in close agreement with the size expected from the nucleotide sequence after removal of introns.
|SHEEP ANTI-c-fos POLYCLONAL ANTIBODY - Data Sheet|