OP17L Anti-c-Fos (Ab-1) Mouse mAb (2G9C3)

OP17L
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      H, M, R M Monoclonal Antibody

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      OP17L-200UG
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      Discontinued
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          Glass bottle 200 μg
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          Description
          OverviewRecognizes both the ~55 kDa c-Fos and ~62 kDa v-Fos proteins in HeLa cells. Does not cross-react with the ~39 kDa Jun protein.
          Catalogue NumberOP17L
          Brand Family Calbiochem®
          References
          ReferencesJensen, D.E., et al. 1991. Oncogene 6, 1219.
          Reiss, M., et al. 1990. Cancer Res. 50, 6641.
          RouscherIII, F.J., et al. 1988. Science 240, 1010.
          Sassone-Corsi, P., et al. 1988. Cell 54, 553.
          Giardina, S.L., et al. 1987. Anal Biochem. 161, 109.
          Verma, I.M., et al. 1987. Cancer Res. 49, 29.
          Verma, I.M., et al. 1987. Cell 51, 513.
          Muller, R. 1986. Viochem. Biophys. Acta. 823, 207.
          Verma, P. 1986. Trends Genet. 2, 93.
          Greenberg, M., et al. 1984. Nature (London) 311, 433.
          Product Information
          FormLyophilized
          FormulationLyophilized from a volatile buffer, 200 µg BSA.
          Positive controlHeLa cells
          PreservativeNone
          Applications
          Key Applications Immunoblotting (Western Blotting)
          Immunocytochemistry
          Not Paraffin Sections
          Application NotesImmunoblotting (2.5-5 µg/ml)
          Immunocytochemistry (2.5-5 µg/ml)
          Paraffin Sections (not recommended)
          Application CommentsRecognizes both cellular and viral forms of fos. Does not react with the ~39 kDa jun protein. Antibody should be titrated for optimal results in individual systems.
          Biological Information
          Immunogena synthetic peptide (KVEQLSPEEEEKRRIRRERNKMAAA) corresponding to amino acids 128-152 of human c-Fos
          ImmunogenHuman
          Clone2G9C3
          HostMouse
          IsotypeIgG2a
          Species Reactivity
          • Human
          • Mouse
          • Rat
          Antibody TypeMonoclonal Antibody
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsReconstitute in sterile PBS, PH 7.4, or sterile Tris-saline (20 mM Tris containing 150 mM NaCl), pH 7.4, to a final concentration of 200 µg/ml. To achieve complete solubilization, reconstitute at (4°C) with 0.1% sodium azide or aliqout and freeze (-20°C) for long-term storage. Note: sodium azide is cytotoxic.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Anti-c-Fos (Ab-1) Mouse mAb (2G9C3) SDS

          Title

          Safety Data Sheet (SDS) 

          Anti-c-Fos (Ab-1) Mouse mAb (2G9C3) Certificates of Analysis

          TitleLot Number
          OP17L

          References

          Reference overview
          Jensen, D.E., et al. 1991. Oncogene 6, 1219.
          Reiss, M., et al. 1990. Cancer Res. 50, 6641.
          RouscherIII, F.J., et al. 1988. Science 240, 1010.
          Sassone-Corsi, P., et al. 1988. Cell 54, 553.
          Giardina, S.L., et al. 1987. Anal Biochem. 161, 109.
          Verma, I.M., et al. 1987. Cancer Res. 49, 29.
          Verma, I.M., et al. 1987. Cell 51, 513.
          Muller, R. 1986. Viochem. Biophys. Acta. 823, 207.
          Verma, P. 1986. Trends Genet. 2, 93.
          Greenberg, M., et al. 1984. Nature (London) 311, 433.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-October-2007 RFH
          ApplicationImmunoblotting (2.5-5 µg/ml)
          Immunocytochemistry (2.5-5 µg/ml)
          Paraffin Sections (not recommended)
          DescriptionPurified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing splenocytes with AG.8653X mouse myeloma cells. Recognizes the ~55 kDa c-fos and the ~62 kDa v-fos proteins.
          BackgroundThe proto-oncogene fos has been implicated in cell growth, differentiation, and development. Proto-oncogene fos is induced by a large number of stimuli ranging from mitogens, differentiation-specific agents, pharmacological agents, etc. Induction of the 62,000 dalton fos protein is rapid but transient. The fos protein is associated with a 39,000 dalton protein which has been identified as the protein product of the jun proto-oncogene (c-jun). The fos/jun protein complex binds specifically to a sequence element in DNA referred to as the AP-1 binding site.
          HostMouse
          Immunogen speciesHuman
          Immunogena synthetic peptide (KVEQLSPEEEEKRRIRRERNKMAAA) corresponding to amino acids 128-152 of human c-Fos
          Clone2G9C3
          IsotypeIgG2a
          Specieshuman, mouse, rat
          Positive controlHeLa cells
          FormLyophilized
          FormulationLyophilized from a volatile buffer, 200 µg BSA.
          PreservativeNone
          CommentsRecognizes both cellular and viral forms of fos. Does not react with the ~39 kDa jun protein. Antibody should be titrated for optimal results in individual systems.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsReconstitute in sterile PBS, PH 7.4, or sterile Tris-saline (20 mM Tris containing 150 mM NaCl), pH 7.4, to a final concentration of 200 µg/ml. To achieve complete solubilization, reconstitute at (4°C) with 0.1% sodium azide or aliqout and freeze (-20°C) for long-term storage. Note: sodium azide is cytotoxic.
          Toxicity Standard Handling
          ReferencesJensen, D.E., et al. 1991. Oncogene 6, 1219.
          Reiss, M., et al. 1990. Cancer Res. 50, 6641.
          RouscherIII, F.J., et al. 1988. Science 240, 1010.
          Sassone-Corsi, P., et al. 1988. Cell 54, 553.
          Giardina, S.L., et al. 1987. Anal Biochem. 161, 109.
          Verma, I.M., et al. 1987. Cancer Res. 49, 29.
          Verma, I.M., et al. 1987. Cell 51, 513.
          Muller, R. 1986. Viochem. Biophys. Acta. 823, 207.
          Verma, P. 1986. Trends Genet. 2, 93.
          Greenberg, M., et al. 1984. Nature (London) 311, 433.

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          Categories

          Life Science Research > Antibodies and Assays > Primary Antibodies