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MABE332 | Anti-c-ErbB2/c-Neu Antibody, clone 9G6

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IP, IHC M Purified Monoclonal Antibody
      Catalogue NumberMABE332
      DescriptionAnti-c-ErbB2/c-Neu Antibody, clone 9G6
      Alternate Names
      • Receptor tyrosine-protein kinase erbB-2
      • Metastatic lymph node gene 19 protein
      • MLN 19
      • Proto-oncogene Neu
      • Proto-oncogene c-ErbB-2
      • Tyrosine kinase-type cell surface receptor HER2
      • p185erbB2
      • CD340
      Background InformationThe ErbB2 (HER2, c-Neu, ErbB2, c-erbB2, or HER2/neu) protein is member of the human epidermal growth factor receptor (HER) family. It is a receptor tyrosine kinase containing an intracellular kinase domain and an extracellular ligand domain, although no endogenous ligand has yet been found. ErbB2 dimerizes with ErbB1, 3, and 4, and can activate different pathways including the PI3K, PLCγ, and MAPK pathways, depending on the ErbB receptor involved. Coupling with ErbB3 activates the PI3K pathway, whereas coupling with any of these three receptors can induce the MAPK pathway. ErbB2 signaling promotes cell proliferation and inhibits apoptosis. ErbB2 is overexpressed in various cancers and may play a role in the development and metastasis of gliomas, and ovarian, breast, lung, and gastric cancer.
      Product Information
      • SK-BR-3 cell lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationUse Anti-c-ErbB2/c-Neu Antibody, clone 9G6 (Mouse Monoclonal Antibody) validated in IP & IHC to detect c-ErbB2/c-Neu also known as MLN 19, Proto-oncogene Neu or Proto-oncogene c-ErbB-2.
      Key Applications
      • Immunoprecipitation
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected c-ErbB2/c-Neu in human breast cancer tissue.
      Biological Information
      ImmunogenWhole cells overexpressing human c-ErbB2/c-Neu.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ERBB2
      • HER2
      • MLN19
      • NEU
      • NGL
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~185 kDa observed. Uniprot describes four isoforms at ~138 kDa (isoform 1), ~63 kDa (isoform 2), ~71 kDa (isoform 3), and ~137 kDa (isoform 4), which can be highly glycosylated and phosphorylated. This antibody may detect one or more isoforms.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunoprecipitation in SK-BR-3 cell lysate.

      Immunoprecipitation Analysis: 10 µg of this antibody immunoprecipitated c-ErbB2/c-Neu from 100 µg of SK-BR-3 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies