OP67 Anti-c-ErbB2/c-Neu (Ab-6) Mouse mAb (OD-3)

OP67
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      H M Monoclonal Antibody

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      OP67-100UG
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      Stocked 
      Discontinued
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      Available
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          Plastic ampoule 100 μg
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          Description
          OverviewRecognizes the ~97-115 kDa truncated form of c-ErbB2/c-Neu in human serum as well as the ~185 kDa full-length protein. Does not cross-react with the EGF receptor.
          Catalogue NumberOP67
          Brand Family Calbiochem®
          SynonymsAnti-HER2, Anti-Neu, Anti-ErbB2, Anti-Erythroblastosis Virus, Anti-Human Epidermal Growth Factor
          References
          ReferencesCarney, W.P, et al. 1991. J. Tumor Marker Oncol. 6, 53.
          DiFiore, P.P., et al. 1987. Science 237, 178.
          Slamon, D.J., et al. 1987. Science 235, 177.
          Varley, J.M., et al. 1987. Oncogene 1, 423.
          Yamamoto, T., et al. 1986. Nature 319, 230.
          Blick, M., et al. 1984. Blood 64, 1234.
          Schwab, M., et al. 1984. Cold Spring Harbor Laboratory 2, 215.
          Bargmann, C.I., et al. 1968. Nature 319, 226.
          Product Information
          FormLiquid
          FormulationIn 50 mM sodium phosphate buffer, 0.2% gelatin.
          Negative controlHT 1080 or HepG2 cells
          Positive controlSK-BR-3 cell conditioned medium
          Preservative≤0.1% sodium azide
          Applications
          Application ReferencesImmunoblotting Carney, W.P, et al. 1991. J. Tumor Marker Oncol. 6, 53.
          Key Applications Not Immunoprecipitation
          Not Paraffin Sections
          Immunoblotting (Western Blotting)
          Not Frozen Sections
          Not Immunofluorescence
          Application NotesImmunoblotting (10 µg/ml)
          Frozen Sections (not recommended)
          Paraffin Sections (not recommended)
          Immunofluorescence (not recommended)
          Immunoprecipitation (not recommended)
          Application CommentsThis antibody reacts with an extracellular epitope and does not cross react with human EGF-receptor. For best results, use IgM-specific secondary reagents. Antibody should be titrated for optimal results in individual systems.
          Biological Information
          Immunogencells overexpressing human c-Neu
          ImmunogenHuman
          CloneOD-3
          HostMouse
          IsotypeIgM
          Species Reactivity
          • Human
          Antibody TypeMonoclonal Antibody
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Yes
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Anti-c-ErbB2/c-Neu (Ab-6) Mouse mAb (OD-3) SDS

          Title

          Safety Data Sheet (SDS) 

          Anti-c-ErbB2/c-Neu (Ab-6) Mouse mAb (OD-3) Certificates of Analysis

          TitleLot Number
          OP67

          References

          Reference overview
          Carney, W.P, et al. 1991. J. Tumor Marker Oncol. 6, 53.
          DiFiore, P.P., et al. 1987. Science 237, 178.
          Slamon, D.J., et al. 1987. Science 235, 177.
          Varley, J.M., et al. 1987. Oncogene 1, 423.
          Yamamoto, T., et al. 1986. Nature 319, 230.
          Blick, M., et al. 1984. Blood 64, 1234.
          Schwab, M., et al. 1984. Cold Spring Harbor Laboratory 2, 215.
          Bargmann, C.I., et al. 1968. Nature 319, 226.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-October-2007 RFH
          SynonymsAnti-HER2, Anti-Neu, Anti-ErbB2, Anti-Erythroblastosis Virus, Anti-Human Epidermal Growth Factor
          ApplicationImmunoblotting (10 µg/ml)
          Frozen Sections (not recommended)
          Paraffin Sections (not recommended)
          Immunofluorescence (not recommended)
          Immunoprecipitation (not recommended)
          DescriptionPurified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing with SP2/0 mouse myeloma cells. Recognizes the ~185 kDa full-length and the ~97-115 kDa truncated forms of c-ErbB2/c-Neu.
          BackgroundAmplification of the human proto-oncogene c-neu occurs in approximately 30% of breast carcinomas and the amplification maybe a useful predictor of disease prognosis. Gene amplification and the resulting overexpression of proto-oncogene encoded proteins is thought to transform cells by chronically stimulating signal transduction pathways and in model systems overexpression of human c-neu induces cellular transformation. In the rat model system, a point mutation has been located within the transmembrane domain of the c-neu oncogene. neu (from neuroglioblastomas) is also referred to as erbB-2 (from erythroblastosis virus) and HER2 (for Human Epidermal Growth Factor Receptor) and was the second of four members of the EGF receptor family to be described.
          HostMouse
          Immunogen speciesHuman
          Immunogencells overexpressing human c-Neu
          CloneOD-3
          IsotypeIgM
          Specieshuman, not mouse, not rat
          Positive controlSK-BR-3 cell conditioned medium
          Negative controlHT 1080 or HepG2 cells
          FormLiquid
          FormulationIn 50 mM sodium phosphate buffer, 0.2% gelatin.
          Concentration Label Please refer to vial label for lot-specific concentration
          Preservative≤0.1% sodium azide
          CommentsThis antibody reacts with an extracellular epitope and does not cross react with human EGF-receptor. For best results, use IgM-specific secondary reagents. Antibody should be titrated for optimal results in individual systems.
          Storage +2°C to +8°C
          Do Not Freeze Yes
          Toxicity Standard Handling
          ReferencesCarney, W.P, et al. 1991. J. Tumor Marker Oncol. 6, 53.
          DiFiore, P.P., et al. 1987. Science 237, 178.
          Slamon, D.J., et al. 1987. Science 235, 177.
          Varley, J.M., et al. 1987. Oncogene 1, 423.
          Yamamoto, T., et al. 1986. Nature 319, 230.
          Blick, M., et al. 1984. Blood 64, 1234.
          Schwab, M., et al. 1984. Cold Spring Harbor Laboratory 2, 215.
          Bargmann, C.I., et al. 1968. Nature 319, 226.
          Application referencesImmunoblotting Carney, W.P, et al. 1991. J. Tumor Marker Oncol. 6, 53.