A part of MilliporeSigma

AB6022 | Anti-beta Arrestin 2 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberAB6022
      DescriptionAnti-beta Arrestin 2 Antibody
      Alternate Names
      • Cone arrestin
      • Retinal cone arrestin-3
      • arrestin 3, retinal (X-arrestin)
      • arrestin 4
      Background InformationThe Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta Arrestin 1), Arrestin 3 (beta Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta Arrestins 1 and 2 are ubiquitously expressed. Beta Arrestins appear to act as negative regulators on G protein-coupled receptors, (Lefkowitz, 1998). Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases, (Lin, 1998; Miller, 2001).
      Product Information
      FormatAffinity Purified
      • Fetal human brain tissue lysate
      PresentationPurified in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-beta Arrestin 2 Antibody is an antibody against beta Arrestin 2 for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to an internal, near C-terminus, epitope of beta Arrestin 2.
      EpitopeNear C-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThe antibody recognizes human beta Arrestin 2 protein.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with ape and chimp based on sequence homology. Additional sequence homology (91%) is noted with mouse and rat.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ARRX
      • C-arrestin
      • CAR
      • X-arrestin
      • cArr
      Purification MethodAntigen Affinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.
      TISSUE SPECIFITY: Inner and outer segments, and the inner plexiform regions of the retina.
      SEQUENCE SIMILARITIES: Belongs to the arrestin family.
      Molecular Weight~ 46 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated on a representative lot by Western blot on fetal brain tissue lysate using Anti-beta Arrestin 2.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information