A part of MilliporeSigma

ABF197 | Anti-ZIP-8 Antibody

100 μg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABF197
      DescriptionAnti-ZIP-8 Antibody
      Alternate Names
      • Zinc transporter ZIP8
      • BCG-induced integral membrane protein in monocyte clone 103 protein
      • LIV-1 subfamily of ZIP zinc transporter 6
      • LZT-Hs6
      • Solute carrier family 39 member 8
      • ZIP-8
      • Zrt- and Irt-like protein 8
      Background InformationZinc transporter ZIP8 (UniProt Q9C0K1; also known as BCG-induced integral membrane protein in monocyte clone 103 protein, LIV-1 subfamily of ZIP zinc transporter 6, LZT-Hs6, Solute carrier family 39 member 8, ZIP-8, Zrt- and Irt-like protein 8) is encoded by the SLC39A8 (also known as BIGM103, ZIP8, PP3105) gene (Gene ID 64116) in human. Zinc transporters mediate the transport of zinc ions into intracellular compartments as well as the export of excess zinc out of cells. Disruption of zinc homeostasis is responsible for many chronic neurodegenerative diseases and acute neural injuries. Excessive and inadequate levels of bioavailable zinc are detrimental to the health of neurons. Two classes of multipass transmembrane Zn transporters are known, including 10 ZnTs and 14 ZIPs, that exhibit opposing functions in mediating zinc homeostasis. These transporters are located on plasma and vesicular membranes with tissue-specific expression pattern. ZIP8 is a negative regulator of the NF-κB signaling pathway through zinc-mediated suppression of IKK activity in monocytes, macrophages, and lung epithelia. ZIP8 expression is induced following innate immune activation and correlates with intracellular zinc sequestration. Human ZIP8 is an 8-transmembrane protein (a.a. 9-29, 133-153, 161-181, 192-212, 303-323, 366-386, 389-409, 430-450) that has both its N- and C-termini (a.a. 1-8 & 451-460) exposed extracelluarly with 4 intracellular and 3 extracellular loops in between.
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationThis Anti-ZIP-8 Antibody is validated for use in Western Blotting for the detection of ZIP-8.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a sequence within the second extracellular loop of human ZIP-8.
      EpitopeSecond extracellular loop.
      ConcentrationPlease refer to lot specific datasheet.
      SpecificityImmunogen sequence is present in all three spliced isoforms of human ZIP-8 reported by UniProt (Q9C0K1).
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Non-Human Primate based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLC39A8
      • BIGM103
      • ZIP8
      • PP3105
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~52 kDa observed. Target band size appears larger than the calculated molecular weights of 49.63/43.13/48.09 kDa (human isoform 1/2/3) due to glycosylation.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human lung tissue lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected ZIP-8 in 10 µg of human lung tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information