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MAB5504 | Anti-Vesicular Glutamate Transporter 2 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB, IHC M Purified Monoclonal Antibody
      Catalogue NumberMAB5504
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Vesicular Glutamate Transporter 2 Antibody
      Alternate Names
      • VGLUT2
      Background InformationVesicular Glutamate Transporter 2 (VGLUT2) is a sodium dependent inorganic phosphate cotransporter that is involved in the calcium dependent glutamate release from astrocytes. It is expressed in only a subset of neurons, localized to synaptic vesicles, at synapses exhibiting classical excitatory features. VGLUT2 mRNA is found in brain regions that lack VGLUT1, a related protein also displaying sodium dependent inorganic phosphate cotransporter activity.
      Product Information
      • Brain tissue
      PresentationMouse monoclonal in PBS containing 0.1% sodium azide.
      ApplicationDetect Vesicular Glutamate Transporter 2 using this Anti-Vesicular Glutamate Transporter 2 Antibody validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry: A 1:50-1:300 dilution of a previous lot worked using ABC with NiDAB on floating mouse brain sections.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRecombinant protein from rat VGLUT2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityReacts with VGLUT2 (Vesicular Glutamate Transporter 2).
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteMouse and rat. Expected to react with human based on sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLC17A6
      • DNPI
      • VGLUT2
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. May also mediate the transport of inorganic phosphate.
      SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome.
      TISSUE SPECIFICITY: Expressed in brain (at protein level). Expressed in brainstem, deep nuclei, septal nuclei, nuclei of the diagonal band, frontal cortex, hypothalamus, midbrain, parietal cortex and temporal cortex. Also expressed in pineal gland and islets of Langerhans.
      SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.

      SIZE: 582 amino acids; 64392 Da
      Molecular Weight56 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot on Mouse brain lysates.

      Western Blotting Analysis: 1:500 dilution of this antibody detected VGLUT2 on 10 µg of Mouse brain lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Vesicular Glutamate Transporter -2641670 2641670
      Anti-Vesicular Glutamate Transporter -2789802 2789802
      Anti-Vesicular Glutamate Transporter -2817471 2817471
      Anti-Vesicular Glutamate Transporter 2 - 2142176 2142176
      Anti-Vesicular Glutamate Transporter 2 - 2393926 2393926
      Anti-Vesicular Glutamate Transporter 2 - 1976404 1976404
      Anti-Vesicular Glutamate Transporter 2 - 2012363 2012363
      Anti-Vesicular Glutamate Transporter 2 - 2043193 2043193
      Anti-Vesicular Glutamate Transporter 2 - 2090451 2090451
      Anti-Vesicular Glutamate Transporter 2 - 2225163 2225163
      Anti-Vesicular Glutamate Transporter 2 - 2322521 2322521
      Anti-Vesicular Glutamate Transporter 2 - LV1513608 LV1513608
      Anti-Vesicular Glutamate Transporter 2 - LV1616024 LV1616024
      Anti-Vesicular Glutamate Transporter 2 - LV1679499 LV1679499
      Anti-Vesicular Glutamate Transporter 2 - LV1728131 LV1728131
      Anti-Vesicular Glutamate Transporter 2 - LV1761053 LV1761053
      Anti-Vesicular Glutamate Transporter 2 - LV1823333 LV1823333
      Anti-Vesicular Glutamate Transporter 2 -2489062 2489062
      Anti-Vesicular Glutamate Transporter 2 -2514062 2514062
      Anti-Vesicular Glutamate Transporter 2 -2677793 2677793
      Anti-Vesicular Glutamate Transporter 2 -2697594 2697594
      Anti-Vesicular Glutamate Transporter 2 -2710703 2710703
      Anti-Vesicular Glutamate Transporter 2 -2727239 2727239
      Anti-Vesicular Glutamate Transporter 2 -2746408 2746408
      Anti-Vesicular Glutamate Transporter 2 -2765956 2765956
      Anti-Vesicular Glutamate Transporter 2 -2780452 2780452

      References | 40 Available | See All References

      Reference overviewApplicationSpeciesPub Med ID
      Dopaminergic and glutamatergic microdomains in a subset of rodent mesoaccumbens axons.
      Zhang, S; Qi, J; Li, X; Wang, HL; Britt, JP; Hoffman, AF; Bonci, A; Lupica, CR; Morales, M
      Nature neuroscience 18 386-92 2015

      Show Abstract
      25664911 25664911
      Interplay between glucose and leptin signalling determines the strength of GABAergic synapses at POMC neurons.
      Lee, DK; Jeong, JH; Chun, SK; Chua, S; Jo, YH
      Nature communications 6 6618 2015

      Show Abstract
      25808323 25808323
      Processing of visually evoked innate fear by a non-canonical thalamic pathway.
      Wei, P; Liu, N; Zhang, Z; Liu, X; Tang, Y; He, X; Wu, B; Zhou, Z; Liu, Y; Li, J; Zhang, Y; Zhou, X; Xu, L; Chen, L; Bi, G; Hu, X; Xu, F; Wang, L
      Nature communications 6 6756 2015

      Show Abstract
      25854147 25854147
      Cerebellar zonal patterning relies on Purkinje cell neurotransmission.
      White, JJ; Arancillo, M; Stay, TL; George-Jones, NA; Levy, SL; Heck, DH; Sillitoe, RV
      The Journal of neuroscience : the official journal of the Society for Neuroscience 34 8231-45 2014

      Show Abstract
      24920627 24920627
      Histological features of layers and sublayers in cortical visual areas V1 and V2 of chimpanzees, macaque monkeys, and humans.
      Balaram, P; Young, NA; Kaas, JH
      Eye and brain 2014 5-18 2014

      Show Abstract
      25788835 25788835
      Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum.
      Ebner, BA; Ingram, MA; Barnes, JA; Duvick, LA; Frisch, JL; Clark, HB; Zoghbi, HY; Ebner, TJ; Orr, HT
      The Journal of neuroscience : the official journal of the Society for Neuroscience 33 5806-20 2013

      Show Abstract
      23536093 23536093
      Establishment of topographic circuit zones in the cerebellum of scrambler mutant mice.
      Reeber, SL; Loeschel, CA; Franklin, A; Sillitoe, RV
      Frontiers in neural circuits 7 122 2013

      Show Abstract
      23885237 23885237
      Reduction of mutant ataxin-7 expression restores motor function and prevents cerebellar synaptic reorganization in a conditional mouse model of SCA7.
      Furrer, SA; Waldherr, SM; Mohanachandran, MS; Baughn, TD; Nguyen, KT; Sopher, BL; Damian, VA; Garden, GA; La Spada, AR
      Human molecular genetics 22 890-903 2013

      Show Abstract
      23197655 23197655
      Torsin A Localization in the Mouse Cerebellar Synaptic Circuitry.
      Puglisi, F; Vanni, V; Ponterio, G; Tassone, A; Sciamanna, G; Bonsi, P; Pisani, A; Mandolesi, G
      PloS one 8 e68063 2013

      Show Abstract
      23840813 23840813
      Multiple knockout mouse models reveal lincRNAs are required for life and brain development.
      Sauvageau, M; Goff, LA; Lodato, S; Bonev, B; Groff, AF; Gerhardinger, C; Sanchez-Gomez, DB; Hacisuleyman, E; Li, E; Spence, M; Liapis, SC; Mallard, W; Morse, M; Swerdel, MR; D'Ecclessis, MF; Moore, JC; Lai, V; Gong, G; Yancopoulos, GD; Frendewey, D; Kellis, M; Hart, RP; Valenzuela, DM; Arlotta, P; Rinn, JL
      eLife 2 e01749 2013

      Show Abstract
      24381249 24381249

      Data Sheet

      Anti-Vesicular Glutamate Transporter 2 - Data Sheet

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