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AB5398 | Anti-Vanilloid Receptor Like Protein 1 Antibody, pain, CT

AB5398
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R IHC Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB5398
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Vanilloid Receptor Like Protein 1 Antibody, pain, CT
      Alternate Names
      • VRL-1
      References
      Product Information
      FormatSerum
      PresentationRabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
      Applications
      ApplicationAnti-Vanilloid Receptor Like Protein 1 Antibody, pain, C-terminus detects level of Vanilloid Receptor Like Protein 1 & has been published & validated for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:1,000-1:2,000 on rat dorsal root ganglia.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenPeptide corresponding to the C-terminal 18 amino acids of the rat VRL-1 protein sequence (Acc#: AAD26364). This immunogen sequence is 100% conserved in the mouse growth factor regulated calcium channel (Acc#: AB021665)
      EpitopeC-terminus
      HostRabbit
      SpecificityVanilloid receptor like protein 1 (VRL-1). Immunohistochemical analysis of rat dorsal root ganglia and spinal cord indicates that this antibody is of high specificity.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.
      Gene Symbol
      • TRPV2
      • VRL
      • TrpV2
      • VRL-1
      • OTRPC2
      • MGC12549
      • VRL1
      Non-Reactive Species
      • Human
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y5S1 # Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.
      SIZE: 764 amino acids; 85981 Da
      SUBUNIT: Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with RGA (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity). Melanosome. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
      PTM: N-glycosylated (By similarity). & Phosphorylated by PKA (By similarity).
      SIMILARITY: SwissProt: Q9Y5S1 ## Belongs to the transient receptor family. TrpV subfamily. & Contains 3 ANK repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-VANILLOID RECEPTOR LIKE PROTEIN 1 POLYCLONAL ANTIBODY 2485464
      RABBIT ANTI-VANILLOID RECEPTOR LIKE PROTEIN 1 POLYCLONAL ANTIBODY - 2148209 2148209
      RABBIT ANTI-VANILLOID RECEPTOR LIKE PROTEIN 1 POLYCLONAL ANTIBODY - 2370580 2370580
      RABBIT ANTI-VANILLOID RECEPTOR LIKE PROTEIN 1 POLYCLONAL ANTIBODY - 2410976 2410976
      RABBIT ANTI-VANILLOID RECEPTOR LIKE PROTEIN 1 POLYCLONAL ANTIBODY - 2016613 2016613
      RABBIT ANTI-VANILLOID RECEPTOR LIKE PROTEIN 1 POLYCLONAL ANTIBODY - 2060936 2060936
      RABBIT ANTI-VANILLOID RECEPTOR LIKE PROTEIN 1 POLYCLONAL ANTIBODY - 2270330 2270330
      RABBIT ANTI-VANILLOID RECEPTOR LIKE PROTEIN 1 POLYCLONAL ANTIBODY - 2315607 2315607
      RABBIT ANTI-VANILLOID RECEPTOR LIKE PROTEIN 1 POLYCLONAL ANTIBODY -2505157 2505157
      RABBIT ANTI-VANILLOID RECEPTOR LIKE PROTEIN 1 POLYCLONAL ANTIBODY -2521592 2521592
      RABBIT ANTI-VANILLOID RECEPTOR LIKE PROTEIN 1 POLYCLONAL ANTIBODY -2579531 2579531
      RABBIT ANTI-VANILLOID RECEPTOR LIKE PROTEIN 1 POLYCLONAL ANTIBODY -2579667 2579667
      RABBIT ANTI-VANILLOID RECEPTOR LIKE PROTEIN 1 POLYCLONAL ANTIBODY -2640553 2640553
      RABBIT ANTI-VANILLOID RECEPTOR LIKE PROTEIN 1 POLYCLONAL ANTIBODY -2712285 2712285

      References

      Reference overviewPub Med ID
      Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise.
      Naticchioni, M; Karani, R; Smith, MA; Onusko, E; Robbins, N; Jiang, M; Radzyukevich, T; Fulford, L; Gao, X; Apel, R; Heiny, J; Rubinstein, J; Koch, SE
      PloS one 10 e0136901 2015

      Show Abstract
      26356305 26356305
      TRPV2 is critical for the maintenance of cardiac structure and function in mice.
      Katanosaka, Y; Iwasaki, K; Ujihara, Y; Takatsu, S; Nishitsuji, K; Kanagawa, M; Sudo, A; Toda, T; Katanosaka, K; Mohri, S; Naruse, K
      Nature communications 5 3932 2014

      Show Abstract
      24874017 24874017
      Thermal sensitivity of isolated vagal pulmonary sensory neurons: role of transient receptor potential vanilloid receptors.
      Ni, D; Gu, Q; Hu, HZ; Gao, N; Zhu, MX; Lee, LY
      American journal of physiology. Regulatory, integrative and comparative physiology 291 R541-50 2006

      Show Abstract
      16513770 16513770
      Identification of kit positive cells in the human urinary tract.
      Frank van der AA, Tania Roskams, Wim Blyweert, Dieter Ost, Guy Bogaert, Dirk De Ridder
      The Journal of urology 171 2492-6 2004

      Show Abstract
      15126883 15126883
      Topography of the vanilloid receptor in the human bladder: more than just the nerve fibers.
      Dieter Ost, Tania Roskams, Frank Van Der Aa, Dirk De Ridder
      The Journal of urology 168 293-7 2002

      Show Abstract
      12050559 12050559

      Data Sheet

      Title
      Anti-Vanilloid Receptor Like Protein 1, pain, C-terminus - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies