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09-408 | Anti-Ubiquitin-protein conjugates Antibody

09-408
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      A WB, IHC Rb Purified Polyclonal Antibody
      Description
      Catalogue Number09-408
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Ubiquitin-protein conjugates Antibody
      OverviewUbiquitin is a small (76 amino acid residues) highly conserved protein and is found in all eukaryotic cells as both a free protein and covalently attached to many other proteins. In the conjugated form it marks proteins for rapid degradation and is also associated with a wide range of cellular functions, including regulation of the cell cycle and control of gene expression. Additionally, it has been found to be enriched in the lysosomes of normal fibroblasts and lymphocytes, suggesting a possible role for ubiquitin in lysosomal degradation of proteins.
      References
      Product Information
      FormatPurified
      Presentation100 µL of purified antiserum. Dilute to working strength with 50mM Tris-HCl buffer (pH 7.6) containing 1.5% sodium chloride and 1% normal goat serum (if a goat anti-rabbit IgG linker antibody is to be used).
      Applications
      ApplicationDetect Ubiquitin-protein conjugates using this Anti-Ubiquitin-protein conjugates Antibody validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      ImmunogenUbiquitin conjugated to KLH.
      HostRabbit
      SpecificityRecognizes ubiquitin-protein conjugates and free ubiquitin on autoclaved nitrocellulose replicas.
      IsotypeIgG
      Species Reactivity
      • All
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
      Gene Symbol
      • RPS27A
      • UBCEP1
      • UBA80
      • Ubiquitin.
      • UBA52
      • UBC
      • CEP80
      • UBB
      • ubiquitin
      • HUBCEP80
      • UBCEP2
      • ubiquitin-CEP80
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P62988 # Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.
      SIZE: 76 amino acids; 8565 Da
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
      PTM: Several types of polymeric chains can be formed, depending on the lysine used for the assembly.
      SIMILARITY: SwissProt: P62988 ## Belongs to the ubiquitin family.
      MISCELLANEOUS: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of shipment for up to 12 months.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      Anti-Ubiquitin-protein conjugates (Rabbit polyclonal IgG) - DAM1431353 DAM1431353
      Anti-Ubiquitin-protein conjugates (Rabbit polyclonal IgG) - DAM1462573 DAM1462573
      Anti-Ubiquitin-protein conjugates - 0611045509 0611045509
      Anti-Ubiquitin-protein conjugates - 1942558 1942558
      Anti-Ubiquitin-protein conjugates - DAM1621681 DAM1621681
      Anti-Ubiquitin-protein conjugates - NG1855870 NG1855870

      References

      Reference overviewPub Med ID
      ΔF508 CFTR surface stability is regulated by DAB2 and CHIP-mediated ubiquitination in post-endocytic compartments.
      Fu, L; Rab, A; Tang, Lp; Bebok, Z; Rowe, SM; Bartoszewski, R; Collawn, JF
      PloS one 10 e0123131 2015

      Show Abstract
      25879443 25879443
      Ubiquitin conjugate immunoreactivity in the brains of scrapie infected mice.
      Lowe, J, et al.
      J. Pathol., 162: 61-6 (1990) 1990

      Show Abstract
      1977900 1977900
      A filamentous inclusion body within anterior horn neurones in motor neurone disease defined by immunocytochemical localisation of ubiquitin
      Lowe, J, et al
      Neurosci Lett, 94:203-10 (1988) 1988

      2853853 2853853

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies