MABS107-I Anti-Ubiquitin K11 linkage Antibody, clone 2A3/2E6

MABS107-I
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, ICC Rb Purified Monoclonal Antibody
      Description
      Catalogue NumberMABS107-I
      DescriptionAnti-Ubiquitin K11 linkage Antibody, clone 2A3/2E6
      Alternate Names
      • Ubiquitin K11 linkage
      • Lysine 11
      Background InformationRecently, the lysine11 (K11) linkage of ubiquitin has been shown to be specifically targeted by the Anaphase-Promoting Complex (APC) E3 ubiquitin ligase for catalyzed ubiquitination for mitosis. Antibodies specific to the K11-linkage have shown that the formation of the K11 chains are greatly increased in mitotic human cells in the presence of APC substrate degradation. K11-linked ubiquitin chains seem to have essential regulatory control over mitotic protein degradation.
      References
      Product Information
      FormatPurified
      PresentationPurified rabbit monoclonal IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-Ubiquitin K11 linkage Antibody, clone 2A3/2E6 is validated for use in western blotting & ICC for the detection of Ubiquitin K11 linkage.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Ubiquitin K11 linkage in A431 and HeLa cells.
      Biological Information
      ImmunogenRecombinant protein corresponding to all in Ubiquitin K11 linkage.
      Clone2A3/2E6
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with All based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • Lys11
      Purification MethodProtein A Purfied
      Molecular WeightVaries
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in K11 recombinant protein.

      Western Blotting Analysis: A 1:250 to 1:1,000 dilution of this antibody detected Ubiquitin K11 linkage in 10 µg of K11 recombinant protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Ubiquitin K11 linkage, clone -26375252637525
      Anti-Ubiquitin K11 linkage, clone -27936052793605
      Anti-Ubiquitin K11 linkage, clone 2A3/2E6 - 24694042469404
      Anti-Ubiquitin K11 linkage, clone 2A3/2E6 - 24945482494548
      Anti-Ubiquitin K11 linkage, clone 2A3/2E6 - 25620172562017
      Anti-Ubiquitin K11 linkage, clone 2A3/2E6 - Q2329862Q2329862
      Anti-Ubiquitin K11 linkage, clone 2A3/2E6 -25834512583451
      Anti-Ubiquitin K11 linkage, clone 2A3/2E6 -26073172607317
      Anti-Ubiquitin K11 linkage, clone 2A3/2E6 -26436372643637
      Anti-Ubiquitin K11 linkage, clone 2A3/2E6 -28445852844585