A part of MilliporeSigma

MABS107 | Anti-Ubiquitin K11 linkage Antibody, clone 2A3/2E6, rabbit monoclonal

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, A WB, IP, ICC Rb Purified Monoclonal Antibody
      Catalogue NumberMABS107
      DescriptionAnti-Ubiquitin K11 linkage Antibody, clone 2A3/2E6, rabbit monoclonal
      Alternate Names
      • Ubiquitin K11 linkage
      • Lysine 11
      Background InformationRecently, the lysine11 (K11) linkage of ubiquitin has been shown to be specifically targeted by the Anaphase-Promoting Complex (APC) E3 ubiquitin ligase for catalyzed ubiquitination for mitosis. Antibodies specific to the K11-linkage have shown that the formation of the K11 chains are greatly increased in mitotic human cells in the presence of APC substrate degradation. K11-linked ubiquitin chains seem to have essential regulatory control over mitotic protein degradation.
      Product Information
      • K11-only Ubn-ubiquitinylated HM substrate protein
      PresentationPurified recombinant rabbit monoclonal IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-Ubiquitin K11 linkage Antibody, clone 2A3/2E6 is an antibody against Ubiquitin K11 linkage for use in WB, IP & IC.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Immunocytochemistry
      Application NotesImmunoprecipitation Analysis: A representative lot was used to detect Ubiquitin K11 linkage in MuRF1.

      Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected Ubiquitin K11 linkage in HeLa and A431 cells.
      Biological Information
      ImmunogenFull length di-ubiquitin dimer linked at K11
      Species Reactivity
      • Human
      • All
      Species Reactivity NoteDemonstrated to react with Human. Predicted to react with all species based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • Lys11
      Purification MethodProtein A
      Molecular Weightvarious
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in K11-only Ubn-ubiquitinylated HM substrate protein.

      Western Blot Analysis: 1:1,000 dilution of this antibody detected Ubiquitin K11 linkage on 10 µg of K11-only Ubn-ubiquitinylated HM substrate protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information


      Certificates of Analysis

      TitleLot Number
      Anti-Ubiquitin K11 linkage, clone 2A3/2E6 - 2021885 2021885
      Anti-Ubiquitin K11 linkage, clone 2A3/2E6 - NG1916517 NG1916517
      Anti-Ubiquitin K11 linkage, clone 2A3/2E6 - NG1931438 NG1931438
      Anti-Ubiquitin K11 linkage, clone 2A3/2E6 - NRG1889945 NRG1889945


      Reference overviewPub Med ID
      K63 polyubiquitination is a new modulator of the oxidative stress response.
      Silva, GM; Finley, D; Vogel, C
      Nature structural & molecular biology 22 116-23 2015

      Show Abstract
      25622294 25622294