MABN741 | Anti-TrpV3 cation channel Antibody, clone N15/4

MABN741
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB, IHC, ICC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABN741
      DescriptionAnti-TrpV3 cation channel Antibody, clone N15/4
      Alternate Names
      • Protein Trpv3
      Background InformationThe protein named Transient receptor potential cation channel subfamily V member 3 or TrpV3, or alternatively Vanilloid receptor-like 3 (VRL-3) and encoded by the human gene TRPV3 is a non-selective cation channel important in temperature sensation and vasoregulation. TrpV3 is expressed for instance in the sensory neurons of the skin and is activated by temperature. TrpV3 also plays a role in keratinocytes proliferation in hair growth; TrpV3 suppression promotes growth, over activation results in apoptosis and hair follicle regression. Indeed TrpV3 is often deemed the most important TRP (transient receptor potential) channel in keratinocytes of the skin. TrpV3 is widely expressed in the CNS and in the keratinocytes of the skin and epithelial tissues. In the brain TrpV3 channels appear to be important for mood regulation and TrpV3 appears to modulate some anti-inflammatory responses in the brain mediated by the anti-inflammatory agent incensole acetate. TrpV3 is also regulated by calcium, ATP and calmodulin, and while it is considered a temperature sensor, recent research challenges that somewhat but TrpV3 still plays important roles in other skin functions such as cutaneous sensations, hair development and barrier function, and mutations in TrpV3 have been linked to a rare genodermatosis known as the Olmsted syndrome.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-TrpV3 cation channel Antibody, clone N15/4 is a highly specific mouse monoclonal antibody, that targets TrpV3 & has been tested in western blotting, IHC & ICC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunocytochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TrpV3 cation channel in human cerebral cortex tissue.
      Immunocytochemistry Analysis: A representative lot detected TrpV3 cation channel in HEK293 cells (Prof. J. Trimmer, University of California, Davis).
      Biological Information
      ImmunogenLinear peptide corresponding to the C-terminus of rat TrpV3 cation channel.
      EpitopeC-terminus
      CloneN15/4
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman, Mouse. Predicted to react with Rat based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Trpv3
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~85 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Neuro-2a cell lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected TrpV3 cation channel in 10 µg of Neuro-2a cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications