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CBL47 | Anti-Transferrin Receptor Antibody

CBL47
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H ELISA Rb Purified Polyclonal Antibody
      Description
      Catalogue NumberCBL47
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Transferrin Receptor Antibody
      Alternate Names
      • CD71
      • TFR
      References
      Product Information
      FormatPurified
      PresentationThe polyclonal is presented at 100μg in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Applications
      ApplicationDetect Transferrin Receptor using this Anti-Transferrin Receptor Antibody validated for use in ELISA.
      Key Applications
      • ELISA
      Application NotesStudy of cellular proliferation and lymphocyte activation.

      Cell surface expression of transferrin receptors is correlated with relative cell growth rate of malignant and non-malignant cells.

      Transferrin receptors are virtually absent from resting PBLs.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenPurified human placental transferring receptor
      HostRabbit
      SpecificityHuman Transferrin Receptor which is expressed on proliferating lymphoblasts, majority human tumour cell lines, normal peripheral blood monocytes.



      Antigen Distribution:

      Con A activated lymphocytes__________67 + 27%

      PHA activated lymphocytes___________67 + 27%

      Monocytes________________________40 + 20%

      Thymocytes_______________________22 + 7%

      Peripheral blood lymphocytes_________< 3%

      B cells (E-)________________________< 1%

      T cells (E+)________________________< 1%

      NK cells (CD16+)___________________< 1%

      Granulocytes_______________________< 1%
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TFRC
      • TfR
      • T9
      • TfR1
      • TFR
      • p90
      • Trfr
      • TR
      • TFR1
      • CD71
      • TRFR
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P02786 # Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
      SIZE: 760 amino acids; 84871 Da
      SUBUNIT: Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3.
      SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. & Transferrin receptor protein 1, serum form: Secreted.
      PTM: N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. & Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR). & Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
      SIMILARITY: SwissProt: P02786 ## Belongs to the peptidase M28 family. M28B subfamily. & Contains 1 PA (protease associated) domain.
      MISCELLANEOUS: Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients. & Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-HUMAN TRANSFERRIN RECEPTOR POLYCLONAL ANTIBODY - 2139962 2139962
      RABBIT ANTI-HUMAN TRANSFERRIN RECEPTOR POLYCLONAL ANTIBODY - 2038227 2038227
      RABBIT ANTI-HUMAN TRANSFERRIN RECEPTOR POLYCLONAL ANTIBODY - 2090901 2090901
      RABBIT ANTI-HUMAN TRANSFERRIN RECEPTOR POLYCLONAL ANTIBODY - 2109485 2109485
      RABBIT ANTI-HUMAN TRANSFERRIN RECEPTOR POLYCLONAL ANTIBODY - 2159624 2159624
      RABBIT ANTI-HUMAN TRANSFERRIN RECEPTOR POLYCLONAL ANTIBODY - 2193210 2193210
      RABBIT ANTI-HUMAN TRANSFERRIN RECEPTOR POLYCLONAL ANTIBODY - 2207119 2207119
      RABBIT ANTI-HUMAN TRANSFERRIN RECEPTOR POLYCLONAL ANTIBODY - 2293686 2293686
      RABBIT ANTI-HUMAN TRANSFERRIN RECEPTOR POLYCLONAL ANTIBODY -2591352 2591352
      RABBIT ANTI-HUMAN TRANSFERRIN RECEPTOR POLYCLONAL ANTIBODY -2592700 2592700

      References

      Reference overviewApplicationPub Med ID
      Promyelocytic leukemia bodies tether to early endosomes during mitosis.
      Palibrk, V; Lång, E; Lång, A; Schink, KO; Rowe, AD; Bøe, SO
      Cell cycle (Georgetown, Tex.) 13 1749-55 2014

      Show Abstract
      24675887 24675887
      Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells.
      Linford, A; Yoshimura, S; Nunes Bastos, R; Langemeyer, L; Gerondopoulos, A; Rigden, DJ; Barr, FA
      Developmental cell 22 952-66 2012

      Show Abstract
      22595670 22595670
      Clathrin-mediated endocytosis is inhibited during mitosis.
      Fielding, AB; Willox, AK; Okeke, E; Royle, SJ
      Proceedings of the National Academy of Sciences of the United States of America 109 6572-7 2012

      Show Abstract
      22493256 22493256
      Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.
      Shi, Y; Kirwan, P; Smith, J; Robinson, HP; Livesey, FJ
      Nature neuroscience 15 477-86, S1 2012

      Show Abstract
      Immunocytochemistry22306606 22306606
      Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.
      Yoshimura, S; Gerondopoulos, A; Linford, A; Rigden, DJ; Barr, FA
      The Journal of cell biology 191 367-81 2010

      Show Abstract Full Text Article
      20937701 20937701

      Brochure

      Title
      Human Stem Cell Systems

      Data Sheet

      Title
      Anti-Transferrin Receptor - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies