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MAB5550 | Anti-TorsinA Antibody

MAB5550
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R IP, WB, ICC M Ascites Monoclonal Antibody
      Description
      Catalogue NumberMAB5550
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-TorsinA Antibody
      Background InformationTorsinA can regulate the cellular trafficking of the dopamine transporter, as well as other polytopic membrane-bound proteins, including G protein-coupled receptors, transporters, and ion channels. TorsinA is found in the dopamine neurons that are lost in PD, and is a component of Lewy bodies. in addition, a genetic defect in TorsinA underlies Torsion dystonia, a disease characterized by painful muscle contractions that result in uncontrollable distortions.
      References
      Product Information
      FormatAscites
      Control
      • Positive Control: Human brain lysate, NGF treated PC12 cells.
      PresentationLiquid. Contaings no preservative
      Applications
      ApplicationThis Anti-TorsinA Antibody is validated for use in IP, WB, IC for the detection of TorsinA.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunocytochemistry
      Biological Information
      ImmunogenMaltose binding protein fusion protein from human torsinA.
      HostMouse
      SpecificityTorsinA
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1.
      Gene Symbol
      • TOR1A
      • DQ1
      • DYT1
      • TOR1B
      • DQ2
      Purification MethodAscites
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O14656 # May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.
      SIZE: 332 amino acids; 37809 Da
      SUBUNIT: Interacts with TOR1AIP1 and TOR1AIP2.
      SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Nucleus membrane. Note=Mainly located in the lumen of the endoplasmic reticulum. Also found associated with the nuclear envelope. The Glu-303 del variant is lumenally-oriented in discrete large spheroid intracellular structures rather than in the endoplasmic reticulum.
      TISSUE SPECIFICITY: Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also high expression in the spinal cord.
      DISEASE: SwissProt: O14656 # Defects in TOR1A are the cause of torsion dystonia 1 (DYT1) [MIM:128100]; also known as primary or idiopathic dystonia. This autosomal dominant disorder is the most common and severe type of dystonia manifesting itself as sustained muscle contractions inducing twisting and repetitive movements and/or abnormal posture. Symptoms usually begin in the arms or legs at a mean age of 12 years and progress to other body parts within 5 years.
      SIMILARITY: SwissProt: O14656 ## Belongs to the clpA/clpB family. Torsin subfamily.
      Molecular Weight37kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-TORSINA -2783091 2783091
      MOUSE ANTI-TORSINA MONOCLONAL ANTIBODY - 2428734 2428734
      MOUSE ANTI-TORSINA MONOCLONAL ANTIBODY - 2262690 2262690
      MOUSE ANTI-TORSINA MONOCLONAL ANTIBODY -2698539 2698539

      References

      Reference overviewPub Med ID
      Developmental patterns of torsinA and torsinB expression
      Vasudevan, Anju, et al
      Brain Res, 1073-1074:139-45 (2006) 2006

      16458269 16458269
      Perinuclear biogenesis of mutant torsin-A inclusions in cultured cells infected with tetracycline-regulated herpes simplex virus type 1 amplicon vectors.
      Bragg, D C, et al.
      Neuroscience, 125: 651-61 (2004) 2004

      Show Abstract
      15099679 15099679
      TorsinB--perinuclear location and association with torsinA.
      Hewett, Jeffrey W, et al.
      J. Neurochem., 89: 1186-94 (2004) 2004

      Show Abstract
      15147511 15147511
      The early onset dystonia protein torsinA interacs with kinesin light chain 1
      Kamm, C. et al.
      J. Biol. Chem., 279(19):19882-19892 (2004) 2004

      14970196 14970196
      TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress.
      Hewett, Jeffrey, et al.
      J. Neurosci. Res., 72: 158-68 (2003) 2003

      Show Abstract
      12671990 12671990

      Data Sheet

      Title
      Anti-TorsinA - Data Sheet