MABT75 | Anti-Titin (NT/Z-domain) Antibody, clone 17D11.1

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB, IH(P) M Purified Monoclonal Antibody
      Catalogue NumberMABT75
      DescriptionAnti-Titin (NT/Z-domain) Antibody, clone 17D11.1
      Alternate Names
      • Titin
      • Connectin
      • Rhabdomyosarcoma antigen MU-RMS-40.14
      Background InformationTitin is a large complex protein containing over one hundred IgG-like and fibronectin type-III domains, in addition to multiple Kelch, RCC1, TPR, and WD repeats. It is a member of the CAMK Ser/Thr protein kinase family and also possesses a protein kinase domain, which is involved in controlling gene expression and protein turnover in muscle tissues. Titin also functions as a sensor to mediate appropriate cellular responses to mechanical stress. In striated muscle tissue, titin regulates the length of the sarcomere by integrating myosin and actin filaments at the Z-disk and M-band, and facilitates the elasticity of the sarcomere. Titin also regulates sarcomere assembly and functions as central hub in signal transduction pathways. Defects in Titin may contribute to various forms of cardiomyopathy.
      Product Information
      • Human and mouse cardiac muscle tissues
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-Titin (N-terminal/Z-domain) Antibody, clone 17D11.1 is an antibody against Titin (N-terminal/Z-domain) for use in Western Blotting, IHC(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Titin.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TTN
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight38 kDa calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human and mouse cardiac muscle tissues.

      Immunohistochemistry Analysis: 1:1,000 dilution of this antibody detected Titin in human and mouse cardiac muscle tissues.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Titin (N-terminal/Z-domain), clone 17D11.1 - 2433594 2433594
      Anti-Titin (N-terminal/Z-domain), -2724172 2724172
      Anti-Titin (N-terminal/Z-domain), -2774076 2774076
      Anti-Titin (N-terminal/Z-domain), clone 17D11.1 - Q2015738 Q2015738
      Anti-Titin (N-terminal/Z-domain), clone 17D11.1 Monoclonal Antibody 2897254
      Anti-Titin (N-terminal/Z-domain), clone 17D11.1-2831762 2831762
      Anti-Titin (N-terminal/Z-domain),clone 17D11.1 -2887577 2887577


      New Products: Volume 3, 2012

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      Life Science Research > Antibodies and Assays > Primary Antibodies