ST1070 Anti-Tiam1 Rabbit pAb

ST1070
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      H, M Rb Polyclonal Antibody

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      ST1070-50UG
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          Plastic ampoule 50 μg
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          Description
          OverviewRecognizes the ~200 kDa Tiam1 protein in Jurkat and NIH3T3 cells.
          Catalogue NumberST1070
          Brand Family Calbiochem®
          SynonymsAnti-T-Cell Lymphoma Invasion and Metastasis 1
          Application Data
          Detection of mouse and human Tiam1 by immunoblotting. Samples: whole cell lysate from HIH3T3 cells (50 µg, lane 1) and Jurkat cells (25 µg, lane 2). Primary antibody: Anti-Tiam1 Rabbit pAb (Cat. No. ST1070) (1:1000). Detection: chemiluminescence.
          References
          ReferencesMertens, A.E., et al. 2003. FEBS Lett. 546, 11.
          Qi, H., et al. 2001. Cell Growth Differ. 12, 603.
          Stam, J.C., et al. 1997. J. Biol. Chem. 272, 28447.
          Product Information
          FormLiquid
          FormulationIn Tris-Citrate/phosphate, pH 7.0-8.0.
          Positive controlJurkat or NIH3T3 cells
          Preservative≤0.1% sodium azide
          Applications
          Key Applications Immunoblotting (Western Blotting)
          Application NotesImmunoblotting (1:1000)
          Application CommentsAntibody should be titrated for optimal results in individual systems.
          Biological Information
          Immunogena synthetic peptide corresponding to amino acids from the C-terminal domain of human Tiam1
          ImmunogenHuman
          HostRabbit
          IsotypeIgG
          Species Reactivity
          • Human
          • Mouse
          Antibody TypePolyclonal Antibody
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Highly Toxic
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Anti-Tiam1 Rabbit pAb SDS

          Title

          Safety Data Sheet (SDS) 

          Anti-Tiam1 Rabbit pAb Certificates of Analysis

          TitleLot Number
          ST1070

          References

          Reference overview
          Mertens, A.E., et al. 2003. FEBS Lett. 546, 11.
          Qi, H., et al. 2001. Cell Growth Differ. 12, 603.
          Stam, J.C., et al. 1997. J. Biol. Chem. 272, 28447.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-October-2007 RFH
          SynonymsAnti-T-Cell Lymphoma Invasion and Metastasis 1
          ApplicationImmunoblotting (1:1000)
          Application Data
          Detection of mouse and human Tiam1 by immunoblotting. Samples: whole cell lysate from HIH3T3 cells (50 µg, lane 1) and Jurkat cells (25 µg, lane 2). Primary antibody: Anti-Tiam1 Rabbit pAb (Cat. No. ST1070) (1:1000). Detection: chemiluminescence.
          DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the ~200 kDa Tiam1 protein.
          BackgroundTiam1 (T-cell lymphoma invasion and metastasis 1) was originally identified by its ability to induce invasion by T-lymphoma cells when amplified. Tiam1 is a specific guanine nucleotide exchange factor (GEF) for the GTPase, Rac. By activating Rac1, Tiam1 regulates many cellular functions including actin cytoskeleton dynamics, cell proliferation, and cell survival. Tiam1 activity is regulated by its translocation to the membrane and the subsequent binding of its PH domain to phosphatidylinositol-3,4,5-triphosphate. Tiam1 is cleaved in a caspase-dependent manner in apoptotic cells, rendering it inactive as a result of an inability to translocate to the plasma membrane.
          HostRabbit
          Immunogen speciesHuman
          Immunogena synthetic peptide corresponding to amino acids from the C-terminal domain of human Tiam1
          IsotypeIgG
          Specieshuman, mouse
          Positive controlJurkat or NIH3T3 cells
          FormLiquid
          FormulationIn Tris-Citrate/phosphate, pH 7.0-8.0.
          Concentration Label Please refer to vial label for lot-specific concentration
          Preservative≤0.1% sodium azide
          CommentsAntibody should be titrated for optimal results in individual systems.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles.
          Toxicity Highly Toxic
          ReferencesMertens, A.E., et al. 2003. FEBS Lett. 546, 11.
          Qi, H., et al. 2001. Cell Growth Differ. 12, 603.
          Stam, J.C., et al. 1997. J. Biol. Chem. 272, 28447.