AB19013 Anti-Tenascin Antibody

AB19013
50 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Ch IHC, IH(P), FUNC Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB19013
      ReplacesAB1951
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Tenascin Antibody
      References
      Product Information
      FormatAffinity Purified
      Control
      • Embryonic chicken brain
      PresentationAffinity Purified using immobilized chicken tenascin. Provided as a liquid in PBS, containing no preservatives.
      Applications
      ApplicationAnti-Tenascin Antibody is an antibody against Tenascin for use in IH, IH(P).
      Key Applications
      • Immunohistochemistry
      • Immunohistochemistry (Paraffin)
      • Affects Function
      Application NotesFunction blocking

      Western blot: Antibody recognizes a 220-240kDa band in reduced westerns; antibody reacts best with chicken, followed by human (100X less reactive). Mouse reactivity under reduced conditions is poor.

      Immunohistochemistry: frozen and paraffin embedded tissues; citrate treatment useful for paraffin tissues.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenPurified tenascin from embryonic chicken brain.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityReactive with tenascin from chicken and human by immunohistochemistry. Under reducing conditions, reactivity to chicken is approximately 100X greater than reactivity with human tenascin. Reactivity with mouse tenascin under reducing conditions is poor, but reacts with mouse in paraffin embedded sections.
      Species Reactivity
      • Human
      • Chicken
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TNC
      • Hexabrachion
      • HXB
      • GMEM
      • TN
      • Neuronectin
      • Tenascin-C
      • MGC167029
      • JI
      • TN-C
      • Cytotactin
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P24821 # Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
      SIZE: 2201 amino acids; 240866 Da
      SUBUNIT: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
      PTM: N-glycosylated (By similarity).
      SIMILARITY: SwissProt: P24821 ## Belongs to the tenascin family. & Contains 15 EGF-like domains. & Contains 1 fibrinogen C-terminal domain. & Contains 15 fibronectin type-III domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Tenascin Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Tenascin Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-TENASCIN POLYCLONAL ANTIBODY - 24303452430345
      RABBIT ANTI-TENASCIN - 32570923257092
      RABBIT ANTI-TENASCIN -25101552510155
      RABBIT ANTI-TENASCIN -25548412554841
      RABBIT ANTI-TENASCIN -25865032586503
      RABBIT ANTI-TENASCIN -26380572638057
      RABBIT ANTI-TENASCIN -26890602689060
      RABBIT ANTI-TENASCIN -27015472701547
      RABBIT ANTI-TENASCIN -27183212718321
      RABBIT ANTI-TENASCIN -27394622739462

      References

      Reference overviewApplicationSpeciesPub Med ID
      Expression of pigment epithelium-derived factor and thrombospondin-1 regulate proliferation and migration of retinal pigment epithelial cells.
      Farnoodian, M; Kinter, JB; Yadranji Aghdam, S; Zaitoun, I; Sorenson, CM; Sheibani, N
      Physiological reports  3  2015

      Show Abstract
      25602019 25602019
      Expression of thrombospondin-1 modulates the angioinflammatory phenotype of choroidal endothelial cells.
      Fei, P; Zaitoun, I; Farnoodian, M; Fisk, DL; Wang, S; Sorenson, CM; Sheibani, N
      PloS one  9  e116423  2014

      Show Abstract
      Western Blotting25548916 25548916
      Satellite cell activity is differentially affected by contraction mode in human muscle following a work-matched bout of exercise.
      Hyldahl, RD; Olson, T; Welling, T; Groscost, L; Parcell, AC
      Frontiers in physiology  5  485  2014

      Show Abstract
      25566087 25566087
      The impact of flow-induced forces on the morphogenesis of the outflow tract.
      Biechler, SV; Junor, L; Evans, AN; Eberth, JF; Price, RL; Potts, JD; Yost, MJ; Goodwin, RL
      Frontiers in physiology  5  225  2014

      Show Abstract
      Immunohistochemistry24987377 24987377
      Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice.
      Pascal, LE; Ai, J; Masoodi, KZ; Wang, Y; Wang, D; Eisermann, K; Rigatti, LH; O'Malley, KJ; Ma, HM; Wang, X; Dar, JA; Parwani, AV; Simons, BW; Ittman, MM; Li, L; Davies, BJ; Wang, Z
      PloS one  8  e79542  2013

      Show Abstract
      24260246 24260246
      Aberrant production of extracellular matrix proteins and dysfunction in kidney endothelial cells with a short duration of diabetes.
      Grutzmacher, C; Park, S; Zhao, Y; Morrison, ME; Sheibani, N; Sorenson, CM
      American journal of physiology. Renal physiology  304  F19-30  2013

      Show Abstract
      ImmunohistochemistryRat23077100 23077100
      Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress.
      Zhao, Y; Wang, S; Sorenson, CM; Teixeira, L; Dubielzig, RR; Peters, DM; Conway, SJ; Jefcoate, CR; Sheibani, N
      Molecular and cellular biology  33  4225-40  2013

      Show Abstract
      Dot BlotMouse23979599 23979599
      Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells.
      Palenski, TL; Sorenson, CM; Jefcoate, CR; Sheibani, N
      Laboratory investigation; a journal of technical methods and pathology  93  646-62  2013

      Show Abstract
      Immunoblotting (Western)Mouse23568032 23568032
      BIM deficiency differentially impacts the function of kidney endothelial and epithelial cells through modulation of their local microenvironment.
      Sheibani, N; Morrison, ME; Gurel, Z; Park, S; Sorenson, CM
      American journal of physiology. Renal physiology  302  F809-19  2012

      Show Abstract
      ImmunofluorescenceMouse22169007 22169007
      Hyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy.
      Calve, S; Isaac, J; Gumucio, JP; Mendias, CL
      American journal of physiology. Cell physiology  303  C577-88  2012

      Show Abstract
      ImmunohistochemistryMouse22785117 22785117

      Data Sheet

      Title
      RABBIT ANTI-TENASCIN

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies