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ABN418 | Anti-TRPM4 Antibody

ABN418
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB, IHC Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABN418
      DescriptionAnti-TRPM4 Antibody
      Alternate Names
      • Transient receptor potential cation channel subfamily M member 4
      • hTRPM4
      • Calcium-activated non-selective cation
      • channel 1
      • Long transient receptor potential channel 4
      • LTrpC-4
      • LTrpC4
      • Melastatin-4
      Background InformationTRPM4, also known as Calcium-activated non-selective cation channel 1, Long transient receptor potential channel 4, Melastatin-4 or LTrpC4, and encoded by the gene TRPM4/LTRPC4, is a calcium activated non-selective ion channel for Na+, K+, Cs+ and Li+ ions. TRPM4 plays a central role in membrane depolarization in cardiomyocytes, cortical and dorsal root neurons, endocrine cells, kidney epithelial cells and even hair cells. Additionally, TRPM4 participates in T-cell activation, IL-2 production, blood vessel constriction, insulin secretion and even cell proliferation in various cell types through the up regulation of the beta catenin signaling pathway. TRPM4 is localized to the cell membrane and golgi apparatus and endoplasmic reticulum. TRPM4 is widely expressed. Defects in TRPM4 may be associated with progressive familial heart block disorder which can be a fatal though unpredictable syndrome.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-TRPM4 Antibody detects level of TRPM4 & has been published & validated for use in TRPM4.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TRPM4 in human cerebellum and human prostate tissue.
      Biological Information
      ImmunogenBCP-conjugated linear peptide corresponding to human TRPM4 near the N-terminal.
      EpitopeNear N-terminal
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteHuman, Mouse, Rat. Predicted to react with Chimpanzee, Monkey, Mouse based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TRPM4
      • LTRPC4
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~150 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~130 kDa and ~147 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human cerebellum tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected TRPM4 in 10 µg of human cerebellum tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications