A part of MilliporeSigma

ABE634 | Anti-TRERF1 Antibody

150 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABE634
      DescriptionAnti-TRERF1 Antibody
      Alternate Names
      • Transcriptional-regulating factor 1
      • Breast cancer anti-estrogen resistance 2
      • Transcriptional-regulating protein 132
      • Zinc finger protein rapa
      • Zinc finger transcription factor TReP-132
      • TRERF1
      Background InformationThe protein named Transcriptional-regulating factor 1 or alternatively, Breast cancer anti-estrogen resistance 2, Transcriptional-regulating protein 132, Zinc finger protein rapa or Zinc finger transcription factor TReP-132 and encoded by the human gene named TRERF1 or BCAR2/RAPA/TREP132 is a transcriptional regulator that activates the transcription of important Cytochrome P450 enzymes such as CYP11A1 which catalyzes the conversion of cholesterol to pregnenolone and is the first rate limiting step in steroid hormone synthesis. Highly expressed in thymus, testis and adrenal cortex, TRERF1 is also expressed in many cancers and cell lines of steroidogenic origins including HepG2 and HEK293 cell lines. TRERF1 localizes to the nucleus and interacts with CREB binding proteins as well as EP300 DNA binding proteins. Also TRERF1 has been shown to be a cell growth suppressor by inducing cyclin-dependent kinase inhibitors p21WAF1 and p27Kip1.
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide and 50% glycerol.
      ApplicationAnti-TRERF1 Antibody is a highly specific rabbit polyclonal antibody, that targets Transcriptional-regulating factor 1 & has been tested in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human TRERF1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • TRERF1
      • BCAR2
      • RAPA
      • TREP132
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~130 kDa and ~140 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in MCF7 cell lysate.

      Western Blotting Analysis: A 1:300 dilution of this antibody detected TRERF1 in MCF7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size150 µL
      Transport Information
      Supplemental Information