A part of MilliporeSigma

MABN755 | Anti-TREM-2 Antibody, clone 78

100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
Request Pricing
Limited AvailabilityLimited Availability
Limited Quantities Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers


      Contact Customer Service

      Click To Print This Page


      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, M WB, ICC, FC, Inhibition, IP R Purified Monoclonal Antibody
      Catalogue NumberMABN755
      DescriptionAnti-TREM-2 Antibody, clone 78
      Alternate Names
      • Triggering receptor expressed on myeloid cells 2
      • TREM-2
      • Triggering receptor expressed on monocytes 2
      Background InformationTREM-2, also known as Triggering receptor expressed on myeloid cells 2 or Triggering receptor expressed on monocytes 2, and encoded by the gene Trem2/Trem2a/Trem2b/Trem2c, is a protein that forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. TREM-2 may also have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM-2 is localized to the cell membrane and is a single pass membrane protein. TREM-2 is expressed in immune cells such as microglia and monocytes but the expression varies depending upon the exact tissue and location within the tissue. Defects in TREM-2 may be associated in humans with frontotemporal dementia, Nasu-Hakola disease, and recently an increase risk of Alzheimer's disease.
      Product Information
      PresentationPurified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl without preservatives.
      ApplicationThis Anti-TREM-2 Antibody, clone 78 is validated for use in western blotting, ICC, flow cytometry, inhibition & IP for the detection of TREM-2.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Flow Cytometry
      • Inhibition
      • Immunoprecipitation
      Application NotesImmunocytochemistry Analysis: A representative lot from an independent laboratory detected TREM-2 in TRACP+ osteoclasts (Humprey, M. B., et al. (2006). J Bone Miner Res. 21(2):237-245.).

      Flow Cytometry Analysis: A representative lot from an independent laboratory detected TREM-2 in RAW264.7 cells (Humprey, M. B., et al. (2006). J Bone Miner Res. 21(2):237-245.).

      Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated TREM-2 from mouse macrophage lysates (Peng, Q., et al. (2010). Sci Signal. 3(122):ra38.).

      Inhibition Analysis: : Pre-treatment of BV2 cells or C57BL/6 Osteoclasts with a representative lot of this antibody significantly reduces cellular activation in response to both untreated and apoptotic Neuro2A cells (Hsieh, C. L., et al. (2009). J Neurochem. (109):4:1144-1156.; Humprey, M. B., et al. (2006). J Bone Miner Res. 21(2):237-245.).
      Biological Information
      ImmunogenRecombinant protein corresponding to mouse TREM-2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody does not cross react with mouse TREM-1 or TREM-3 (Prof. William Seaman, University of California, San Francisco.).
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Trem2
      • Trem2a
      • Trem2b
      • Trem2c
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~25 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human spleen tissue lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected TREM-2 in 10 µg of human spleen tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-TREM-2, clone 78 - Q2395222 Q2395222
      Anti-TREM-2, clone 78 -2551006 2551006
      Anti-TREM-2, clone 78 -2580719 2580719
      Anti-TREM-2, clone 78 -2623698 2623698
      Anti-TREM-2, clone 78 -2649290 2649290
      Anti-TREM-2, clone 78 -2659640 2659640
      Anti-TREM-2, clone 78 -2702184 2702184
      Anti-TREM-2, clone 78 -2790976 2790976


      Reference overviewPub Med ID
      TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.
      Peng, Qisheng, et al.
      Sci Signal, 3: ra38 (2010) 2010

      Show Abstract
      20484116 20484116
      A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia.
      Hsieh, Christine L, et al.
      J. Neurochem., 109: 1144-56 (2009) 2009

      Show Abstract
      19302484 19302484
      TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function.
      Humphrey, Mary Beth, et al.
      J. Bone Miner. Res., 21: 237-45 (2006) 2006

      Show Abstract
      16418779 16418779