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MABN473 | Anti-TMEM106B Antibody, clone TME-N 6F2

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R WB, IF R Purified Monoclonal Antibody
      Catalogue NumberMABN473
      DescriptionAnti-TMEM106B Antibody, clone TME-N 6F2
      Alternate Names
      • Transmembrane protein 106B
      • TMEM106B
      Background InformationTransmembrane protein 106B (TMEM106B) is a single-pass type II membrane protein present in endosomal and lysosomal membranes, and is highly expressed in the frontal cortex. Increased TMEM106B expression in the brain may be linked to mechanisms of disease in frontotemporal lobar degeneration with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP). Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia.
      Product Information
      • Human cortex tissue lysate
      PresentationPurified rat monoclonal IgG2c in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-TMEM106B, clone TME-N 6F2 detects levels of TMEM106B proteins & has been published & validated for use in WB & IF.
      Key Applications
      • Western Blotting
      • Immunofluorescence
      Application NotesImmunofluorescence Analysis: A 1:50 dilution from a representative lot detected TMEM106B in rat cerebellum tissue.
      Biological Information
      ImmunogenRecombinant protein corresponding to the N-terminus of human TMEM106B.
      CloneTME-N 6F2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes the N-terminus of TMEM106B.
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TMEM106B
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~30 kDa observed (At higher antibody concentrations, this protein may be observed at ~45 kDa.). This protein may be observed at ~50 kDa due to glycosylation (Lang, C. M., et al. (2012). J Biol Chem. 287(23):19355-19365.).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human cortex tissue lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected TMEM106B in 10 µg of human cortex tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-TMEM106B, clone TME-N 6F2 - Q2118750 Q2118750
      Anti-TMEM106B, clone TME-N 6F2 -2524844 2524844
      Anti-TMEM106B, clone TME-N 6F2 -2745869 2745869
      Anti-TMEM106B, clone TME-N 6F2 -2816570 2816570


      Reference overviewPub Med ID
      Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.
      Götzl, JK; Mori, K; Damme, M; Fellerer, K; Tahirovic, S; Kleinberger, G; Janssens, J; van der Zee, J; Lang, CM; Kremmer, E; Martin, JJ; Engelborghs, S; Kretzschmar, HA; Arzberger, T; Van Broeckhoven, C; Haass, C; Capell, A
      Acta neuropathologica 127 845-60 2014

      Show Abstract
      24619111 24619111
      The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes.
      Schwenk, Benjamin M, et al.
      EMBO J., (2014) 2014

      Show Abstract
      24357581 24357581
      Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration.
      Lang, Christina M, et al.
      J. Biol. Chem., 287: 19355-65 (2012) 2012

      Show Abstract
      22511793 22511793

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      Life Science Research > Antibodies and Assays > Primary Antibodies