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MAB13446 | Anti-TIMP-2 Antibody, clone 2TMP05

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, Gp, H, M, R, Rb WB, IH(P) M Purified Monoclonal Antibody
      Catalogue NumberMAB13446
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-TIMP-2 Antibody, clone 2TMP05
      Alternate Names
      • Tissue Inhibitor of Metalloproteinase-2
      Product Information

        Pancreatic or colon carcinoma
      PresentationPurified from ascites fluid by Protein A chromatography. 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
      ApplicationDetect TIMP-2 using this Anti-TIMP-2 Antibody, clone 2TMP05 validated for use in WB, IH(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistology (formalin/paraffin only): 2-4μg/ml 30 min at RT.

      Western blotting: 1μg/ml for 2 hrs at RT.

      (Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min. followed by cooling at RT for 20 min).

      The optimal dilution for a specific application under a given set of experimental conditions should be determined by the investigator.
      Biological Information
      ImmunogenA synthetic peptide from the N-terminal region of human TIMP-2 protein.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityMAB13446 recognizes a protein of 21kDa, identified as tissue inhibitor of metalloproteinase-2 (TIMP-2). TIMP-2 is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. CHEMICON MAB13446 may be used to evaluate the invasive nature of some tumor types and determine the tissue distribution of TIMPs in other tumors such as adenomas and also its normal tissue.


      Species Reactivity
      • Bovine
      • Guinea Pig
      • Human
      • Mouse
      • Rat
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
      Gene Symbol
      • TIMP2
      • TIMP-2
      • CSC-21K
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P16035 # Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
      SIZE: 220 amino acids; 24399 Da
      PTM: The activity of TIMP2 is dependent on the presence of disulfide bonds.
      SIMILARITY: SwissProt: P16035 ## Belongs to the protease inhibitor I35 (TIMP) family. & Contains 1 NTR domain.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsAntibody with sodium azide is stable for 12 months after date of receipt when stored at 2-8°C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-TIMP-2 [Tissue Inhibitor of MMP-2] MONOCLONAL ANTIBODY - 2150705 2150705
      MOUSE ANTI-TIMP-2 [Tissue Inhibitor of MMP-2] MONOCLONAL ANTIBODY - 2383451 2383451
      MOUSE ANTI-TIMP-2 [Tissue Inhibitor of MMP-2] MONOCLONAL ANTIBODY - 2435054 2435054
      MOUSE ANTI-TIMP-2 [Tissue Inhibitor of MMP-2] MONOCLONAL ANTIBODY - 2379281 2379281
      MOUSE ANTI-TIMP-2 -2521291 2521291
      MOUSE ANTI-TIMP-2 -2529634 2529634
      MOUSE ANTI-TIMP-2 -2567098 2567098
      MOUSE ANTI-TIMP-2 -2603250 2603250
      MOUSE ANTI-TIMP-2 [Tissue Inhibitor of MMP-2] MONOCLONAL ANTIBODY - 2251741 2251741
      MOUSE ANTI-TIMP-2 [Tissue Inhibitor of MMP-2] MONOCLONAL ANTIBODY - 2266452 2266452
      MOUSE ANTI-TIMP-2 [Tissue Inhibitor of MMP-2] MONOCLONAL ANTIBODY - 2343382 2343382


      Reference overviewPub Med ID
      Diurnal variation of tight junction integrity associates inversely with matrix metalloproteinase expression in Xenopus laevis corneal epithelium: implications for circadian regulation of homeostatic surface cell desquamation.
      Wiechmann, AF; Ceresa, BP; Howard, EW
      PloS one 9 e113810 2014

      Show Abstract
      25412440 25412440
      Histological, histochemical, and protein changes after induced malocclusion by occlusion alteration of Wistar rats.
      Guerra, Cde S; Carla Lara Pereira, Y; Issa, JP; Luiz, KG; Guimarães, EA; Gerlach, RF; Iyomasa, MM
      BioMed research international 2014 563463 2014

      Show Abstract
      25028660 25028660
      Repeated autologous bone marrow-derived mesenchymal stem cell injections improve radiation-induced proctitis in pigs.
      Linard, C; Busson, E; Holler, V; Strup-Perrot, C; Lacave-Lapalun, JV; Lhomme, B; Prat, M; Devauchelle, P; Sabourin, JC; Simon, JM; Bonneau, M; Lataillade, JJ; Benderitter, M
      Stem cells translational medicine 2 916-27 2013

      Show Abstract
      24068742 24068742
      Angiotensin-II and rosuvastatin influence matrix remodeling in human mesangial cells via metalloproteinase modulation.
      Solini A, Rossi C, Santini E, Madec S, Salvati A, Ferrannini E.
      Journal of hypertension 29 1930-9 2011

      Show Abstract
      21881526 21881526
      HIV-1 gp120 upregulates matrix metalloproteinases and their inhibitors in a rat model of HIV encephalopathy.
      Jean-Pierre Louboutin,Beverly A S Reyes,Lokesh Agrawal,Elisabeth J Van Bockstaele,David S Strayer
      The European journal of neuroscience 34 2011

      Show Abstract
      22092673 22092673
      Effect of doxycycline on postoperative scarring after trabeculectomy in an experimental rabbit model.
      Emine Sen,Melike Balikoglu-Yilmaz,Sibel Bozdag-Pehlivan,Nuran Sungu,Fatma Nur Aksakal,Ayse Altinok,Tulay Tuna,Nursen Unlu,Huseyin Ustun,Gultekin Koklu,Faruk Öztürk
      Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 26 2010

      Show Abstract
      20874665 20874665
      The carboxyl terminal trimer of procollagen I induces pro-metastatic changes and vascularization in breast cancer cells xenografts.
      Visigalli, D; Palmieri, D; Strangio, A; Astigiano, S; Barbieri, O; Casartelli, G; Zicca, A; Manduca, P
      BMC cancer 9 59 2009

      Show Abstract
      19226458 19226458

      Data Sheet

      Anti-TIMP-2, clone 2TMP05 - Data Sheet

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      Life Science Research > Antibodies and Assays > Primary Antibodies