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16-268 | Anti-TCL1 Antibody, Alexa Fluor® 488

25 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC, IF, WB M AlexaFluor®488 Monoclonal Antibody
      Catalogue Number16-268
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-TCL1 Antibody, Alexa Fluor® 488
      Alternate Names
      • T-cell leukemia/lymphoma 1A
      • T-cell lymphoma-1
      • T-cell lymphoma-1A
      Product Information
      ApplicationDetect TCL1 using this Anti-TCL1 Antibody, Alexa Fluor 488 validated for use in FC, IF & WB.
      Key Applications
      • Flow Cytometry
      • Immunofluorescence
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide corresponding to amino acids 60-73 (RPMTPTQIGPSLLP) of human TCL1A.
      SpecificityRecognizes TCL1A isoform, Mr 14kDa. No cross-reactivity with TML1 (TCL1B) or MTCP1.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TCL1A
      • TCL1
      • TCL1-PEN
      UniProt Number
      UniProt SummarySIZE: 114 amino acids; 13460 Da
      SUBUNIT: Homodimer.
      SUBCELLULAR LOCATION: Microsome. Note=Microsomal fraction.
      TISSUE SPECIFICITY: Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
      DISEASE: SwissProt: P56279 # Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta locuses.
      SIMILARITY: SwissProt: P56279 ## Belongs to the TCL1 family.
      Molecular Weight14kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at 4°C from date of shipment
      Packaging Information
      Material Size25 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-TCL1, Alexa Fluorreg; 488 - D6D029 D6D029


      Reference overviewPub Med ID
      Structural basis for the co-activation of protein kinase B by T-cell leukemia-1 (TCL1) family proto-oncoproteins.
      Auguin, Daniel, et al.
      J. Biol. Chem., 279: 35890-902 (2004) 2004

      Show Abstract
      15169787 15169787
      A systematic approach to diagnosis of mature T-cell leukemias reveals heterogeneity among WHO categories
      Herling, M. et al.
      Blood, 104:328-35 (2004) 2004

      15044256 15044256
      TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin
      Herling, M. et al.
      Blood, 101:5007-9 (2003) 2003

      12576313 12576313
      TCL1: a new drug target in lymphoid and germ-cell malignancies?
      Lock, Richard B
      Int. J. Biochem. Cell Biol., 35: 1614-8 (2003) 2003

      Show Abstract
      12962701 12962701

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      Life Science Research > Antibodies and Assays > Primary Antibodies