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MABN1041 | Anti-TAB3 Antibody, clone EPR5965, rabbit monoclonal

100 µL  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB, IF Rb Unpurified Monoclonal Antibody
      Catalogue NumberMABN1041
      DescriptionAnti-TAB3 Antibody, clone EPR5965, rabbit monoclonal
      Alternate Names
      • TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
      • Mitogen-activated protein kinase kinase kinase 7-interacting protein 3
      • NF-kappa-B-activating protein 1
      • TAK1-binding protein 3
      • TAB-3
      • TGF-beta-activated kinase 1-binding protein 3
      • TAB3
      Background InformationTAB3 protein, or alternatively known as TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1 binding protein 3 (TAB-3), TGF-beta-activated kinase 1-binding protein 3 and encoded by the human gene named TAB3 or MAP3K7IP3 is a coordinating linker kinase in the TNF and IL-1 signaling pathways and also plays a role in the activation of the NF-kappa-B and AP1 gene activation pathways. These pathways play critical roles in many cellular pathways including immune responses, stress responses, apoptosis, proliferation and differentiation, and dysfunction of these pathways has been associated with numerous cancer and immune disorders. TAB3 is also involved in general MAPK activations and receptor signaling pathways, and TAB3 is important in Toll-like receptor signaling as well. TAB3 interacts with signaling partners TRAF6 and TRAF2 as well as TAB1, TAB2, and MAP3K7. The kinase is widely expressed in most tissues, and particularly upregulated in various cancer tissues. EMD-Millipore’s Anti-TAB3 rabbit monoclonal antibody has been tested in western blot against 293T, HepG2, HeLa, Caco-2, RAW264.7 and NIH3T3 cell lysates and in fluorescent immunocytochemistry on HepG2 cells in culture.
      Product Information
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      ApplicationAnti-TAB3 Antibody, clone EPR5965 is a highly specific rabbit monoclonal antibody, that targets TAB3 & has been tested in western blotting & Immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunofluorescence
      Application NotesImmunofluorescence Analysis: A 1:50 dilution from a representative lot detected TAB3 in HepG2 cells.
      Biological Information
      ImmunogenSynthetic peptide corresponding to human TAB3.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • TAB3
      • MAP3K7IP3
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~90 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HEK293T, HepG2, HeLa, Caco-2, RAW264.7, and NIH/3T3 cell lysates.

      Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected TAB3 in HEK293T, HepG2, HeLa, Caco-2, RAW264.7, and NIH/3T3 cell lysates.

      Optimal working dilutions must be determined by end user.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies