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AB5883 | Anti-Synapsin I Antibody, phosphoSer 603

AB5883
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB5883
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Synapsin I Antibody, phosphoSer 603
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin presented as a liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
      Applications
      ApplicationAnti-Synapsin I Antibody, phosphoSer 603 detects level of Synapsin I & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:1,000. Rat brain lysate shows a ~78-80kDa band.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to amino acids surrounding the phosphoSer603 of rat Synapsin I. The immunogen sequence is identical in human, mouse and Xenopus.
      EpitopephosphoSer 603
      HostRabbit
      SpecificitySynapsin I, phosphoSer603. This is the site phosphorylated by Calcium calmodulin kinase II. The antibody recognizes the ~78 kD Synapsin I, phosphoSer603 protein. Immunolabeling is blocked by the immunogen peptide but no by the corresponding non-phospho peptide.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
      Gene Symbol
      • SYN1
      • SYN1a
      • Synapsin-1
      • SYNI
      • SYN1b
      Modifications
      • Phosphorylation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17600 # Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
      SIZE: 705 amino acids; 74111 Da
      SUBUNIT: Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1 (By similarity).
      SUBCELLULAR LOCATION: Cell junction, synapse.
      PTM: Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
      DISEASE:SwissProt: P17600 # Defects in SYN1 are a cause of X-linked recessive epilepsy associated with variable learning disabilities and behavior disorders [MIM:300491].
      SIMILARITY: SwissProt: P17600 ## Belongs to the synapsin family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-SYNAPSIN I phosphoSer603 -2806481 2806481
      RABBIT ANTI-SYNAPSIN I phosphoSer603 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 1998935 1998935
      RABBIT ANTI-SYNAPSIN I phosphoSer603 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2001241 2001241
      RABBIT ANTI-SYNAPSIN I phosphoSer603 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2270506 2270506

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)

      Data Sheet

      Title
      Anti-Synapsin I, phosphoSer 603 - Data Sheet