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MABE369 | Anti-Suv4–20h2 Antibody, clone 6B9

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB R Purified Monoclonal Antibody
      Catalogue NumberMABE369
      DescriptionAnti-Suv4–20h2 Antibody, clone 6B9
      Alternate Names
      • Histone-lysine N-methyltransferase SUV420H2
      • Lysine N-methyltransferase 5C
      • Suppressor of variegation 4-20 homolog 2
      • Su(var)4-20 homolog 2
      • Suv4-20h2
      Background InformationSuppressor of variegation 4-20 homolog 2 (Suv4-20h2), also known as Lysine N-methyltransferase 5C (KMT5C), is a Histone-lysine N-methyltransferase that specifically trimethylates Lys-20 of histone H4. Suv4-20h2 mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. In mammals, Histone H4 Lys-20 trimethylation (H4K20me3) is one of the most common chromatin modifications and it has been implicated in various biological processes, including heterochromatin formation, telomere function, imprinting, X inactivation, DNA damage repair and cancer progression.
      Product Information
      • H9 human embryonic stem cell lysate
      PresentationPurified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect the Suv4–20h2 protein using this Anti-Suv4–20h2, clone 6B9 validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Suv4-20h2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SUV420H2
      • KMT5C
      • PP7130
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~53 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~11 kDa and ~15 kDa.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in H9 human embryonic stem cell lysate.

      Western Blot Analysis: 4.0 µg/mL of this antibody detected Suv4-20h2 in 10 µg of H9 human embryonic stem cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Suv4#8211;20h2, clone 6B9 - Q2112550 Q2112550


      Reference overviewApplicationPub Med ID
      Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin.
      Hahn, M; Dambacher, S; Dulev, S; Kuznetsova, AY; Eck, S; Wörz, S; Sadic, D; Schulte, M; Mallm, JP; Maiser, A; Debs, P; von Melchner, H; Leonhardt, H; Schermelleh, L; Rohr, K; Rippe, K; Storchova, Z; Schotta, G
      Genes & development 27 859-72 2013

      Show Abstract
      23599346 23599346
      CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin.
      Dambacher, S; Deng, W; Hahn, M; Sadic, D; Fröhlich, J; Nuber, A; Hoischen, C; Diekmann, S; Leonhardt, H; Schotta, G
      Nucleus (Austin, Tex.) 3 101-10 2012

      Show Abstract
      Immunofluorescence22540025 22540025

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      Life Science Research > Antibodies and Assays > Primary Antibodies