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MAB4617 | Anti-Survivin Antibody, clone 8E2

50 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H ELISA, IF M Purified Monoclonal Antibody
      Catalogue NumberMAB4617
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Survivin Antibody, clone 8E2
      Alternate Names
      • TIAP
      Background InformationSurvivin, an inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.
      Product Information
      PresentationPurified immunoglobulin, by Protein G. Liquid in 10 mM PBS, pH 7,4 containing 0.2% BSA and 0.09% sodium azide.
      ApplicationDetect Survivin using this Anti-Survivin Antibody, clone 8E2 validated for use in ELISA & IF.
      Key Applications
      • ELISA
      • Immunofluorescence
      Applications Not Recommended
      • Western Blotting
      Application NotesImmunofluorescence

      ELISA (for detection only)

      Does not work for Western Blot

      Does not work for Immunohistochemistry

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenFull length recombinant human survivin
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityMAB4617 detects human survivin (16.5 kDa).
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
      Gene Symbol
      • BIRC5
      • SVV
      • IAP4
      • survivin
      • EPR-1
      • API4
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O15392 # May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Interacts with tubulin. Inhibitor of caspase-3 and caspase-7. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Isoforms 2 and 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti- apoptotic effects when compared with the displayed wild-type isoform.
      SIZE: 142 amino acids; 16390 Da
      SUBUNIT: Homodimer. When phosphorylated, interacts with HBXIP; the resulting complex binds pro-caspase-9, as well as active caspase- 9, but much less efficiently. Component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B. Interacts with EVI5.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes.
      TISSUE SPECIFICITY: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.
      DOMAIN: SwissProt: O15392 The BIR repeat is necessary and sufficient for HBXIP binding.
      SIMILARITY: Belongs to the IAP family. & Contains 1 BIR repeat.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C for up to 12 months.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-SURVIVIN -2624999 2624999


      Reference overviewPub Med ID
      Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas.
      Lu, C D, et al.
      Cancer Res., 58: 1808-12 (1998) 1998

      Show Abstract
      9581817 9581817
      Control of apoptosis and mitotic spindle checkpoint by survivin.
      Li, F, et al.
      Nature, 396: 580-4 (1998) 1998

      Show Abstract
      9859993 9859993
      A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma.
      Ambrosini, G, et al.
      Nat. Med., 3: 917-21 (1997) 1997

      9256286 9256286

      Data Sheet


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      Life Science Research > Antibodies and Assays > Primary Antibodies