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MABT22 | Anti-Stabilin-Interacting Chitinase-like Protein Antibody, clone 1C11

100 µg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, ICC R Purified Monoclonal Antibody
      Catalogue NumberMABT22
      DescriptionAnti-Stabilin-Interacting Chitinase-like Protein Antibody, clone 1C11
      Alternate Names
      • chitinase domain-containing 1
      • Stabilin-1-interacting chitinase-like protein
      Background InformationStabilin-1-interacting chitinase-like protein (SI-CLP) is a novel protein belonging to the Glyco-18 domain-containing protein family which consists of both true enzymes and secreted chitinase-like proteins that lack enzymatic activity. SI-CLP is secreted by macrophages, and is bound by stabilin-1 which acts to mediate the intracellular sorting of SI-CLP, trafficking it from the trans-golgi network to the system of endosomes and lysosomes. After SI-CLP disassociates from stabilin-1, it is then moved to secretory lysosomes where it is able to be secreted into extracellular space. Currently three isoforms of SI-CLP have been identified; however, the exact function of SI-CLP is yet unknown. Its closest homologues have been implicated as soluble mediators in tumor progression and several disorders involving ECM remodeling and alterations to the vascular system.
      Product Information
      • THP-1 cell lysate
      PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect Stabilin-Interacting Chitinase-like Protein using this Anti-Stabilin-Interacting Chitinase-like Protein Antibody, clone 1C11 validated for use in WB & IC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC. (Kzhyshkowska, 2006; Zhang, 2009)
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Stabilin-Interacting Chitinase-like Protein.
      CloneJul 1C11
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CHID1
      • GL008
      • SI-CLP
      Purification MethodProtein G
      UniProt Number
      UniProt SummarySUBUNIT STRUCTURE: Interacts with STAB1.

      SUBCELLULAR LOCATION: Secreted. Lysosome.

      TISSUE SPECIFICITY: Expressed in cells of monocytic, T, B and epithelial origin.

      INDUCTION: Up-regulated by interleukin-4 and dexamethasone in the macrophages.

      SEQUENCE SIMILARITIES: Belongs to the glycosyl hydrolase 18 family.
      Molecular Weight~ 39 kDa observed MW.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in THP-1 cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Stabilin-Interacting Chitinase-like Protein in 10 µg of THP-1 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information