MABS1922 | Anti-Src-Like-Adaptor 2 (SLA2) Antibody, clone Z30P1F12*F4

NewMABS1922
100 μg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IH(P) M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABS1922
      DescriptionAnti-Src-Like-Adaptor 2 (SLA2) Antibody, clone Z30P1F12*F4
      Alternate Names
      • Modulator of antigen receptor signaling
      • MARS
      • Src-like adapter protein 2
      • SLAP-2
      Background InformationSrc-like-adapter 2 (UniProt: Q9H6Q3; also known as Modulator of antigen receptor signaling; MARS; Src-like adapter protein 2; SLAP-2) is encoded by the SLA2 (also known as SLAP2, C20orf156) gene (Gene ID 84174) in human. SLAP-2 is localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles. The SLAP-2 protein contains an NH2-terminal myristoylation consensus sequence and SH3 and SH2 Src homology domains, but lacks a tyrosine kinase domain. It is predominantly expressed in immune system, including T cells and monocytes and at low levels in B cells, placenta, prostate, colon, and skin. SLAP-2 serves as an adapter protein that negatively regulates T-cell receptor (TCR) signaling and is shown to block T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. In antigen receptor-stimulated cells, SLAP-2 associates with several tyrosine phosphorylated proteins, including the ubiquitin ligase Cbl. Deletion of the carboxyl terminus of SLAP-2 is shown to block its function and abolish its association with Cbl. Overexpression of SLAP-2 in T and B cell lines impairs antigen receptor-mediated signaling events, including the up-regulation of CD69, NFAT promoter activation, and calcium influx. Ref.: Holland, SJ et al. (2001). J. Exp. Med. 194(9):1263-1276. Pandey, A., et al. (2002). J. Biol. Chem. 277(21):19131-19138.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationDetect Src-like-adapter 2 using this mouse monoclonal Anti-Src-Like-Adaptor 2 (SLA2) antibody, clone Z30P1F12*F4, Cat. No. MABS1922, validated for use in Immunohistochemistry (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenA synthetic peptide corresponding to 8 aa from the C-terminal region of human Src-like adapter 2 protein.
      CloneZ30P1F12*F4
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone Z30P1F12*F4 detects -Src-Like-Adaptor 2 (SLA2) protein in human by targeting a sequence in the C-terminal region.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLA2
      • SLAP2
      • C20orf156
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight28.6 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human cervical cancer, pancreas, and tonsil tissue.

      Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Src-Like-Adaptor 2 (SLA2) in human cervical cancer, pancreas, and tonsil tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications