A part of MilliporeSigma

MABS445 | Anti-Sclerostin Antibody, clone 7B6.1 | MABS445

200 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R WB, IHC M Culture Supernatant Monoclonal Antibody
      Catalogue NumberMABS445
      DescriptionAnti-Sclerostin Antibody, clone 7B6.1 | MABS445
      Alternate Names
      • Sclerostin
      Background InformationSclerostin (UniProt Q9BQB4) is encoded by the SOST (also known as CDD, SOST1, VBCH) gene (ORP UNQ2976/PRO7455/PRO7476; Gene ID 50964) in human. Sclerostin is a glycoprotein expressed in osteocytes and functions as a negatively regulator against bone mass by antagonizing low density lipoprotein receptor-related proteins- (LRP5-/LRP6-) mediated WNT/beta-catenin pathway signaling. Sclerostin levels are increased in the post-menopausal women and elderly and in long term immobilized patients. Sclerostin neutralizing antibody is reported to enhance bone formation, mass, and strength in aged male rats. Sclerostin and its inhibitors have potential in prosthetic, regenerative and preventive therapy in dentistry.
      Product Information
      FormatCulture Supernatant
      PresentationMouse monoclonal IgG2bκ antibody tissue culture supernatant without preservatives.
      ApplicationAnti-Sclerostin Antibody, clone 7B6.1 | MABS445 is an antibody against Sclerostin Antibody for use in Western Blotting and Immunohistochemistry.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Sclerostin in human kidney, rat liver and human liver tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the internal fragment of human Sclerostin.
      ConcentrationPlease refer to lot specific datasheet.
      SpecificityDetects Sclerostin isoform 1 (UniProt Q9BQB4-1). Reactivity toward the spliced isoform 2 (UniProt Q9BQB4-2) is likely, but has not been determined.
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SOST
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight24 kDa calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in GST-tagged Sclerostin recombinant protein.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected 0.5 µg of GST-tagged Sclerostin recombinant protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information