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MABF121 | Anti-SV40 Large T Antigen Antibody, clone PAb416

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Sv40 Infected Cells WB, ICC M Purified Monoclonal Antibody
      Catalogue NumberMABF121
      DescriptionAnti-SV40 Large T Antigen Antibody, clone PAb416
      Alternate Names
      • Large T antigen
      • LT
      • LT-AG
      Background InformationBoth the Simian virus (SV40) large T and small T antigens are encoded by the early region of the SV40 genome. The large T antigen binds DNA, and complexes with a 53,000 dalton cellular protein, p53, which is required for initiation of viral DNA replication during lytic growth. In addition the large T antigen binds DNA polymerase and the transcription factor AP-2 and forms a specific complex with the P105 product of the retinoblastoma susceptibility gene.
      Product Information
      • Cos-1 cell lysate
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-SV40 Large T Antigen Antibody, clone PAb416 is an antibody against SV40 Large T Antigen for use in Western Blotting, ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A representative lot from an independent laboratory detected SV40 Large T Antigen in ICC (Sabatier, J., et al. (2005). 58(4):429-431.; Del Valle, L., et al. (2004). J Virol. 78(7):3462-3469.).
      Biological Information
      ImmunogenPurified large T-antigen of SV40
      EpitopeLarge T antigen of SV40
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes the large T antigen of SV40.
      Species Reactivity
      • Sv40 Infected Cells
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~82 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in Cos-1 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected SV40 Large T Antigen in 10 µg of Cos-1 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-SV40 Large T Antigen 2475049
      Anti-SV40 Large T Antigen, clone -2794949 2794949
      Anti-SV40 Large T Antigen, clone -2811989 2811989
      Anti-SV40 Large T Antigen, clone PAb416 - 2262705 2262705
      Anti-SV40 Large T Antigen, clone PAb416 - 2300011 2300011
      Anti-SV40 Large T Antigen, clone PAb416 - Q2013505 Q2013505
      Anti-SV40 Large T Antigen, clone PAb416 -2500704 2500704
      Anti-SV40 Large T Antigen, clone PAb416 -2555305 2555305
      Anti-SV40 Large T Antigen, clone PAb416 -2579926 2579926
      Anti-SV40 Large T Antigen, clone PAb416 -2602793 2602793
      Anti-SV40 Large T Antigen, clone PAb416 -2736399 2736399
      Anti-SV40 Large T Antigen, clone PAb416 -2770277 2770277


      Reference overviewPub Med ID
      Immunodetection of SV40 large T antigen in human central nervous system tumours.
      Sabatier, J, et al.
      J. Clin. Pathol., 58: 429-31 (2005) 2005

      Show Abstract
      15790713 15790713
      Primary central nervous system lymphoma expressing the human neurotropic polyomavirus, JC virus, genome.
      Del Valle, Luis, et al.
      J. Virol., 78: 3462-9 (2004) 2004

      Show Abstract
      15016869 15016869


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