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MAB4423C3 | Anti-SOX-2 Antibody, clone 10H9.1, Cy3 conjugate

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M ICC M Cy3 Monoclonal Antibody
      Catalogue NumberMAB4423C3
      DescriptionAnti-SOX-2 Antibody, clone 10H9.1, Cy3 conjugate
      Alternate Names
      • SOX2
      • ANOP3
      • MCOPS3
      • MGC2413
      • SRY related HMG BOX gene 2
      Background InformationSOX-2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution. Sox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain a pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS. SOX-2 has been identified as a key transcription factor required for cellular reprogramming.
      Product Information
      • Mouse Embryonic Stem Cells (SCR012).
      PresentationPurified mouse monoclonal IgG2b conjugated to Cy3 in PBS with 0.1% sodium azide and 15mg/ml BSA.
      ApplicationAnti-SOX-2 Antibody, clone 10H9.1, Cy3 conjugate is an antibody against SOX-2 for use in ICC.
      Key Applications
      • Immunocytochemistry
      Application NotesEvaluated by Immunocytochemistry in H9 Human Embryonic Stem Cells.
      Immunocytochemsitry Analysis: A 1:100 dilution of this antibody detected SOX-2 in H9 Human Embryonic Stem Cells.
      Biological Information
      Immunogenrecombinant protein corresponding to human SOX-2.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SOX2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight34 kDa calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in Mouse Embryonic Stem Cells (SCR012). Immunocytochemsitry Analysis: A 1:100 dilution of this antibody detected SOX-2 in Mouse Embryonic Stem Cells (SCR012).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8ºC protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies