A part of MilliporeSigma

MABN364 | Anti-SNAP91 Antibody, clone 7H12.1

100 μg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, M WB M Purified Monoclonal Antibody
      Catalogue NumberMABN364
      DescriptionAnti-SNAP91 Antibody, clone 7H12.1
      Alternate Names
      • Clathrin coat assembly protein AP180
      • 91 kDa synaptosomal-associated protein
      • Clathrin coat-associated protein AP180
      • Phosphoprotein F1-20
      • SNAP91
      Background InformationClathrin coat assembly protein AP180 (UniProt O60641), also known as Phosphoprotein F1-20, Assembly protein, 180kDa, 91 kDa synaptosomal-associated protein, Clathrin coat-associated protein AP180, Synaptosomal-associated protein 91kDa homolog) is encoded by the SNAP91 gene in human. Clathrin-mediated endocytosis (CME) is a regulated process for internalization of transmembrane cargo. Clathrin molecules initially assemble into a vesicle coat at the plasma membrane, then a specific cargo sorting process selects and concentrates proteins into the newly formed vesicle. CME mediates traffic to different target membranes for cargo delivery inside cells. Both clathrin assembly and cargo sorting functions are controlled by SNAP91 protein (AP180) and its ubiquitously expressed homolog clathrin assembly lymphoid myeloid leukemia protein (CALM). AP180 mediates clathrin assembly with its C-terminal assembly domain, whose central acidic clathrin and adapter binding (CLAP) sub-domain contains all of the known short binding motifs for clathrin and the adapter complex, AP2. The sequence of the remaining AP180 C-terminal sub-domain is conserved in CALM and functions to ensures efficient clathrin binding.
      Product Information
      PresentationPurified mouse monoclonal IgMκ antibody in buffer containing PBS with 0.05% sodium azide.
      ApplicationAnti-SNAP91 Antibody, clone 7H12.1 is an antibody against SNAP91 for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected SNAP91 in 10 µg of human, mouse, and rat brain tissue lysate.
      Biological Information
      ImmunogenLinear peptide corresponding to human SNAP91 near the C-terminus.
      EpitopeNear C-terminus
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SNAP91
      • KIAA0656
      Purification MethodPurified by Ion-Exchange Chromatography
      UniProt Number
      Molecular Weight~91 kDa observed. This protein has isoforms at ~6, ~63, and ~89 kDa and the antigen sequence spans all isoforms. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SH-SY5Y cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected SNAP91 in 10 µg of SH-SY5Y cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information