06-1376 Anti-SLBP Antibody

06-1376
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB, ICC Rb Serum Polyclonal Antibody
      Description
      Catalogue Number06-1376
      DescriptionAnti-SLBP Antibody
      Alternate Names
      • Histone stem-loop-binding protein
      • hairpin binding protein
      • histone binding protein 2
      • histone stem-loop binding protein
      • stem-loop (histone) binding protein
      • stem-loop binding protein
      • HBP
      • Histone RNA hairpin-binding protein
      Background InformationThe SLPB gene (stem-loop binding protein) encodes a protein that binds to the stem-loop structure of replication-dependent histone pre-mRNAs. Histone mRNA lack a polyadenylation signal. Consequently, the interaction of this protein with histone pre-mRNA contributes to efficient 3' end processing by stabilizing the complex between the pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP). Expression of this protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1.
      References
      Product Information
      FormatSerum
      Control
      • C2C12 cell lysates.
      PresentationSerum in buffer containing 0.05% sodium azide
      Applications
      ApplicationUse Anti-SLBP Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect SLBP also known as Histone stem-loop-binding protein, HBP, Histone RNA hairpin-binding protein.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry:
      Representative lot data.
      Confocal fluorescent analysis of NIH/3T3 cells using 06-1376 (Red). Actin filaments have been labeled with AlexaFluor®488 -Phalloidin (Green). Nucleus is stained with DAPI (Blue). This antibody positively stains cytoplasm and nucleus.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human SLBP.
      EpitopeC-terminus
      HostRabbit
      SpecificityAntibody recognizes SLBP.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteReacts with Human and Mouse. Predicted to react with Rat based on sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq]
      Gene Symbol
      • SLBP
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION:Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3' end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP). Could play an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression By similarity.
      SUBUNIT STRUCTURE:: Monomer. SLBP/pre-mRNA complex interacts with ZNF473. Interacts with MIF4GD By similarity.
      SUBCELLULAR LOCATION:: Cytoplasm. Nucleus. Note: Polyribosome-associated.
      TISSUE SPECIFICITY: Widely expressed.
      SEQUENCE SIMILARITIES: Belongs to the SLBP family.
      Molecular Weight38 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in C2C12 cell lysates.

      Western Blotting Analysis: A 1:1000 dilution of this antibody detected SLBP in C2C12 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications