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ABE102 | Anti-SIRT6 Antibody

ABE102
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABE102
      DescriptionAnti-SIRT6 Antibody
      Alternate Names
      • NAD-dependent deacetylase sirtuin-6
      • SIR2-like protein 6
      Background InformationSIRT6 is one of seven mammalian homologs of the yeast Sir2 histone deacetylase. SIRT6 is a nuclear, chromatin-associated protein that is very important in normal DNA repair and resistance to DNA damage. SIRT6-deficient mice develop severe abnormalities that seem to be closely related to models of normal aging-associated degeneration and die at 4 weeks. SIRT6 has also been associated with other aging-related pathways and may be responsible for normal longevity and homeostasis. Recently, SIRT6 has also been shown to play an important role in glucose metabolism.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HeLa cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-SIRT6 Antibody is a Rabbit Polyclonal Antibody for detection of SIRT6 also known as NAD-dependent deacetylase sirtuin-6, SIR2-like protein 6 & has been validated in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human SIRT6.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes SIRT6 at the C-terminus.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV
      of the sirtuin family. Alternative splicing results in multiple
      transcript variants.
      Gene Symbol
      • SIRT6
      • SIR2L6
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein By similarity.

      CATALYTIC ACTIVITY: NAD+ + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.

      COFACTOR: Binds 1 zinc ion per subunit (By similarity).

      SUBUNIT STRUCTURE: Interacts with RELA.

      SUBCELLULAR LOCATION: Nucleus › nucleoplasm. Note: Predominantly nuclear. Associated with telomeric heterochromatin regions.

      SEQUENCE SIMILARITIES: Belongs to the sirtuin family.

      Contains 1 deacetylase sirtuin-type domain.

      SEQUENCE CAUTION: The sequence AAC34468.1 differs from that shown. Reason: Erroneous gene model prediction.

      The sequence AAD15478.1 differs from that shown. Reason: Erroneous gene model prediction.

      The sequence AAH04218.1 differs from that shown. Reason: Frameshift at position 23.
      Molecular Weight~32 kDa observed. There are three isoforms at 31, 36, and 39 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected SIRT6 on 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies