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04-742 | Anti-SHP-1/2 Antibody, clone NL213, rabbit monoclonal

04-742
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M IP, WB Rb Culture Supernatant Monoclonal Antibody
      Description
      Catalogue Number04-742
      Replaces05-742
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-SHP-1/2 Antibody, clone NL213, rabbit monoclonal
      References
      Product Information
      FormatCulture Supernatant
      PresentationCultured supernantant in 0.05% sodium azide
      Applications
      ApplicationThis Anti-SHP-1/2 Antibody, clone NL213 is validated for use in IP, WB for the detection of SHP-1/2.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenFull-length glutathione transferase SHP-1 fusion protein, purified from bacteria
      CloneNL213
      HostRabbit
      SpecificityRecognizes SHP-1 greater than SHP-2, Mr ~65 kDa
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman and mouse. Others not tested.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
      Gene Symbol
      • PTPN6
      • HCP
      • SH-PTP1
      • PTP-1C
      • SHP1
      • SHP-1L
      • PTP1C
      • HCPH
      • SHP-1
      • HPTP1C
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P29350 # Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
      SIZE: 595 amino acids; 67561 Da
      SUBUNIT: Monomer. Interacts with MTUS1 (By similarity). Binds PTPNS1, LILRB1 and LILRB2. Interacts with FCRL2, CD300LF and CD84.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity).
      TISSUE SPECIFICITY: Isoform 1 is expressed in hematopoietic cells while isoform 2 is expressed in non-hematopoietic cells.
      PTM: Phosphorylated on serine and tyrosine residues.
      SIMILARITY: SwissProt: P29350 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. & Contains 2 SH2 domains. & Contains 1 tyrosine-protein phosphatase domain.
      Molecular Weight~65kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot in RIPA lysates from human A431 carcinoma cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

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      Included Positive Control

      Catalog Number Description  
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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies