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ABC724 | Anti-SH3BP4 Antibody

ABC724
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IHC Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABC724
      DescriptionAnti-SH3BP4 Antibody
      Alternate Names
      • SH3 domain-binding protein 4
      • EH-binding protein 10
      • Transferrin receptor-trafficking protein
      • SH3BP4
      Background InformationSH3 domain-binding protein 4, also known as, EH-binding protein 10 or Transferrin receptor-trafficking protein, and encoded by the gene name(s), SH3BP4 or BOG25 or EHB10 or TTP, may function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation; thereby may indirectly regulate cell growth, proliferation and autophagy.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide and 40% glycerol.
      Applications
      ApplicationAnti-SH3BP4 Antibody is an antibody against SH3BP4 for use in Immunohistochemistry.
      Key Applications
      • Immunohistochemistry
      Biological Information
      ImmunogenRecombinant protein corresponding to human SH3BP4.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • SH3BP4
      • BOG25
      • EHB10
      • TTP
      Purification MethodAffinity
      UniProt Number
      Molecular Weight107 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceImmunohistochemistry Analysis (IHC): A 1:20-50 dilution from a representative lot detected SH3BP4 in human small intestine and smooth muscle tissues.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications