A part of MilliporeSigma

AB3874 | Anti-SENP2 Antibody

100 µg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H ELISA, WB Rb Purified Polyclonal Antibody
      Catalogue NumberAB3874
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-SENP2 Antibody
      Alternate Names
      • Sentrin/SUMO-specific Protease 2
      Product Information
      • POSITIVE CONTROL: Jurkat or NIH3T3 whole cell lysate.
      PresentationImmunoglobulin was purified by protein G affinitychromatography and is presented as a liquid in PBS with 0.09% sodium azide.
      ApplicationThis Anti-SENP2 Antibody is validated for use in ELISA, WB for the detection of SENP2.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1:500 (approximately 69 kDa)

      ELISA: 1:1,000

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to amino acid residues 16-32 of human SENP2

      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityRecognizes human SENP2.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummarySUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM]
      Gene Symbol
      • SENP2
      • AXAM2
      • SMT3IP2
      • Axam2
      • Smt3ip2
      • KIAA1331
      • DKFZp762A2316
      • EC 3.4.22.-
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9HC62 # Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity).
      SIZE: 589 amino acids; 67855 Da
      SUBUNIT: Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus.
      SUBCELLULAR LOCATION: Nucleus, nuclear pore complex; Nucleoplasmic side. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.
      DOMAIN:SwissProt: Q9HC62 The N-terminus is necessary and sufficient for nuclear envelope targeting.
      PTM: Polyubiquitinated; which leads to proteasomal degradation.
      SIMILARITY: Belongs to the peptidase C48 family.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20ºC in undiluted aliquots for up to one year from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information