A part of MilliporeSigma

ABN555 | Anti-SEMA5B Antibody

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IHC Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABN555
      DescriptionAnti-SEMA5B Antibody
      Alternate Names
      • Semaphorin-5B
      • SEMA5B
      Background InformationSemaphorins 5B (Sema5B) belongs to a large family of guidance molecules that are involved in cell migration, axonal guidance, and axonal fasciculation. Sema5B is a transmembrane protein that is proteolytically processed to generate fragments that can function as a soluble growth cone collapsing guidance cue. Majority of semaphorins act as inhibitory molecules. Their inhibitory activity is through a conserved 500 amino acid 'sema' domain, while their alternative functions are associated with their varied C-terminal domains. Over-expression of Sema5B reduces the number of synpases in hippocampus and conversely, depletion of Sema5B results in a significant increase in synaptic number and size. Sema5B is expressed in a variety of regions in the developing brain and its persistent expression at postnatal stages indicates that it continues to contribute to the functioning of neuronal circuits and regulates synaptic functions.
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide and 40% glycerol.
      ApplicationAnti-SEMA5B Antibody is an antibody against SEMA5B for use in Immunohistochemistry.
      Key Applications
      • Immunohistochemistry
      Biological Information
      ImmunogenRecombinant protein corresponding to human SEMA5B.
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • SEMA5B
      • SEMAG
      • UNQ5867/PRO34001
      Purification MethodAffinity
      UniProt Number
      Molecular Weight126 kDa calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceImmunohistochemistry Analysis: A 1:50-100 dilution from a representative lot detected SEMA5B in cerebellum, lateral ventricle, vagina, urinary bladder tissues.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information