A part of MilliporeSigma

MABN98 | Anti-SATB2 Antibody, clone 2B12.2

100 µg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB M Purified Monoclonal Antibody
      Catalogue NumberMABN98
      DescriptionAnti-SATB2 Antibody, clone 2B12.2
      Alternate Names
      • DNA-binding protein SATB2
      • Special AT-rich sequence-binding protein 2
      Background InformationDNA-binding protein SATB2 (SATB2) is also known as Special AT-rich sequence-binding protein 2. SATB2 binds to DNA at nuclear matrix- or scaffold-associated regions. SATB2 is critical for the initiation of the upper-layer neurons (UL1) specific genetic program and the inactivation of deep-layer neurons (DL) and UL2 specific genes, represses Ctip2 and regulates corticocortical connections in the developing cerebral cortex. SATB2 acts as a transcription factor controlling nuclear gene expression by inducing chromatin-loop remodeling. SATB2 is also a docking site for, and recruits chromatin remodeling enzymes, corepressors (HDACs) and coactivators (HATs) directly to promoters and enhancers. SATB2 is highly expressed in adult brain, with moderate to weak expression in fetal brain, adult liver, kidney, spinal cord, amygdala, corpus callosum, caudate nucleus, and hippocampus. Defects and chromosomal aberrations involving SATB2 are found in isolated cleft palate and Toriello-Carey syndrome.
      Product Information
      • Human colon tissue lysate.
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect SATB2 using this mouse monoclonal antibody, Anti-SATB2 Antibody & clone 2B12.2 validated for use in western blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: 1 µg/mL from a representative lot detected SATB2 in 10 µg of Raji cell lysate.

      Western Blotting Analysis: 0.5 µg/mL from a representative lot detected SATB2 in 10 µg mouse, rat, and human cell lysate.
      Biological Information
      ImmunogenRecombinant protein corresponding to human SATB2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SATB2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~78 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human colon tissue lysate.

      Western Blotting Analysis: 0.25 µg/mL of this antibody detected SATB2 in 10 µg of human colon tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies