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MAB10212 | Anti-Renin Antibody, clone F32 VIII C4

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Po WB M Ascites Monoclonal Antibody
      Catalogue NumberMAB10212
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Renin Antibody, clone F32 VIII C4
      Background InformationRenin is processed as a 406 amino acid precursor (45 kDa) containing a 23 amino acid signal peptide and a 43 amino acid propeptide that is released from renal juxtaglomerular cells in response to sodium depletion, decreased blood volume and blood pressure, and b-adrenergic stimulation. Renin initiates a sequence of steps that begins with cleavage of a decapeptide angiotensin I from renin substrate (angiotensinogen), an alpha-2-globulin produced in the liver (and other organs including the kidney.
      Product Information
      PresentationLiquid ascites fluid
      ApplicationAnti-Renin Antibody, clone F32 VIII C4 detects level of Renin & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPurified hog renin
      CloneF32 VIII C4
      Species Reactivity
      • Pig
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryRenin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
      Gene Symbol
      • REN
      • Angiotensinogenase
      • angiotensinogenase
      • renin
      • FLJ10761
      • EC
      Purification MethodAscites
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P00797 # Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
      SIZE: 406 amino acids; 45057 Da
      SUBUNIT: Interacts with ATP6AP2.
      SUBCELLULAR LOCATION: Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2.
      DISEASE: SwissProt: P00797 # Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
      SIMILARITY: SwissProt: P00797 ## Belongs to the peptidase A1 family.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at 2-8°C from date of receipt
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number


      Reference overviewPub Med ID
      Specific prorenin/renin binding (ProBP). Identification and characterization of a novel membrane site
      Sealey, J E, et al
      Am J Hypertens, 9:491-502 (1996) 1996

      8735181 8735181
      Measurement and identification of prorenin and renin in ovarian follicular fluid from cattle and pig.
      Hagemann, A, et al.
      Clin. Exp. Pharmacol. Physiol., 19: 267-73 (1992) 1992

      Show Abstract
      1516275 1516275

      Data Sheet

      Anti-Renin, clone F32 VIII C4 - Data Sheet

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      Life Science Research > Antibodies and Assays > Primary Antibodies