A part of MilliporeSigma

05-1359 | Anti-RXR alpha Antibody, clone 4E9

100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
Request Pricing
Limited AvailabilityLimited Availability
Limited Quantities Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers


      Contact Customer Service

      Click To Print This Page


      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, ICC M Purified Monoclonal Antibody
      Catalogue Number05-1359
      DescriptionAnti-RXR alpha Antibody, clone 4E9
      Alternate Names
      • Nuclear receptor subfamily 2 group B member 1
      • Retinoid X receptor alpha
      • retinoid X receptor, alpha
      Background InformationRetinoid X receptor α (RXRA or RXR alpha) is a nuclear receptor that mediates the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. RXRs as a whole exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulate their transcription.
      Product Information
      • MCF-7 cell lysate
      PresentationPurified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
      ApplicationAnti-RXR alpha Antibody, clone 4E9 is a Mouse Monoclonal Antibody for detection of RXR α also known as Retinoid X receptor alpha & has been validated in WB, ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry: Representative lot data.
      A 1:500 dilution of a previous lot detected Retinoid X Receptor α in A431 cells.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to Retinoid X Receptor α.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody detects Retinoid X Receptor α.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryRetinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. [provided by RefSeq].
      Gene Symbol
      • FLJ00280
      • FLJ00318
      • FLJ16020
      • FLJ16733
      • MGC102720
      • NR2B1
      • OTTHUMP00000022510
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer By similarity.

      SUBUNIT STRUCTURE: Homodimer or forms a heterodimer with peroxisome proliferator activated receptor gamma called adipocyte-specific transcription factor ARF6. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with FAM120B By similarity. Interacts with SFPQ. Interacts with HCV core protein. Interacts with PELP1. Interacts with SENP6. Interacts with DNTTIP2. Interacts with RNF8.


      TISSUE SPECIFICITY: Highly expressed in liver, also found in lung, kidney and heart.

      DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.

      PTM: Sumoylated on Lys-108; which negatively regulates transcriptional activity. Desumoylated specifically by SENP6.

      SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR2 subfamily.

      Contains 1 nuclear receptor DNA-binding domain.

      Molecular Weight51 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by western blot on MCF-7 cell lysate.

      Western Blot Analysis: 0.5-2 µg/mL of this antibody detected Retinoid X Receptor α in MCF-7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8ºC from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information

      Related Products & Applications

      Related Products

      Catalog Number Description  
      FCMAB123F Milli-Mark™ Anti-Retinoid X Receptor α Antibody, clone 4E9, FITC Conjugate Show Pricing & Availability
      MAB5478 Anti-Retinoid X Receptor α Antibody Show Pricing & Availability

      View Gene Related Products for this Target


      Life Science Research > Antibodies and Assays > Primary Antibodies