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07-137 | Anti-RKIP Antibody

07-137
200 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R IP, WB Rb Purified Polyclonal Antibody
      Description
      Catalogue Number07-137
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-RKIP Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationDetect RKIP using this Anti-RKIP Antibody validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenGST-fusion protein corresponding to full-length rat RKIP (Raf kinase inhibitor protein)
      HostRabbit
      SpecificityRKIP
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PEBP1
      • PEBP
      • RKIP
      • HCNP
      • HCNPpp
      • PEBP-1
      • PBP
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P30086 # HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).
      SIZE: 187 amino acids; 21057 Da
      SUBUNIT: Interacts with Raf-1 and seems to inhibit it.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity).
      SIMILARITY: SwissProt: P30086 ## Belongs to the phosphatidylethanolamine-binding protein family.
      Molecular Weight23kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from 3T3 and HeLa cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-RKIP (rabbit polyclonal IgG) - 2349629 2349629
      Anti-RKIP (rabbit polyclonal IgG) - 2208815 2208815
      Anti-RKIP - 2433435 2433435
      Anti-RKIP - 20152 20152
      Anti-RKIP - 2037641 2037641
      Anti-RKIP - DAM1807838 DAM1807838
      Anti-RKIP - JBC1852379 JBC1852379
      Anti-RKIP - JBC1908440 JBC1908440
      Anti-RKIP_2836865 2836865

      References

      Reference overviewApplicationPub Med ID
      Extracellular vesicle-mediated phenotype switching in malignant and non-malignant colon cells.
      Mulvey, HE; Chang, A; Adler, J; Del Tatto, M; Perez, K; Quesenberry, PJ; Chatterjee, D
      BMC cancer 15 571 2015

      Show Abstract
      26231887 26231887
      Raf kinase inhibitor protein (RKIP) blocks signal transducer and activator of transcription 3 (STAT3) activation in breast and prostate cancer.
      Yousuf, S; Duan, M; Moen, EL; Cross-Knorr, S; Brilliant, K; Bonavida, B; LaValle, T; Yeung, KC; Al-Mulla, F; Chin, E; Chatterjee, D
      PloS one 9 e92478 2014

      Show Abstract
      24658061 24658061
      Geographic analysis of RKIP expression and its clinical relevance in colorectal cancer.
      Koelzer, VH; Karamitopoulou, E; Dawson, H; Kondi-Pafiti, A; Zlobec, I; Lugli, A
      British journal of cancer 108 2088-96 2013

      Show Abstract
      23632477 23632477
      RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients.
      Cross-Knorr, S; Lu, S; Perez, K; Guevara, S; Brilliant, K; Pisano, C; Quesenberry, PJ; Resnick, MB; Chatterjee, D
      BMC cancer 13 463 2013

      Show Abstract
      24098947 24098947
      RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy.
      Martinho, O; Pinto, F; Granja, S; Miranda-Gonçalves, V; Moreira, MA; Ribeiro, LF; di Loreto, C; Rosner, MR; Longatto-Filho, A; Reis, RM
      PloS one 8 e59104 2013

      Show Abstract
      Immunohistochemistry23527098 23527098
      Novel proteins associated with human dilated cardiomyopathy: selective reduction in α(1A)-adrenergic receptors and increased desensitization proteins.
      Shi, T; Moravec, CS; Perez, DM
      Journal of receptor and signal transduction research 33 96-106 2013

      Show Abstract
      23384050 23384050
      Proteomic changes in rat spermatogenesis in response to in vivo androgen manipulation; impact on meiotic cells.
      Stanton, PG; Sluka, P; Foo, CF; Stephens, AN; Smith, AI; McLachlan, RI; O'Donnell, L
      PloS one 7 e41718 2012

      Show Abstract
      22860010 22860010
      Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein.
      Yeung, K, et al.
      Mol. Cell. Biol., 20: 3079-85 (2000) 2000

      Show Abstract
      10757792 10757792
      Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP.
      Yeung, K, et al.
      Nature, 401: 173-7 (1999) 1999

      Show Abstract
      10490027 10490027

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies