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ABN645 | Anti-RIM 2 Antibody

ABN645
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R WB, IHC, IF Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABN645
      DescriptionAnti-RIM 2 Antibody
      Alternate Names
      • Regulating synaptic membrane exocytosis protein 2
      • Rab-3-interacting molecule 2
      • RIM 2
      • Rab-3-interacting protein 3
      Background InformationRab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. RIM 1 and RIM 2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like RIM 1, RIM 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Applications
      ApplicationAnti-RIM 2 Antibody is an antibody against RIM 2 for use in western blotting, IHC & immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: 5 μg/mL from a representative lot detected RIM 2 in human brain tissue.

      Immunofluorescence Analysis: 20 μg/mL from a representative lot detected RIM 2 in human brain cells.



      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the center region of human RIM 2.
      Epitopecenter region
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody may recognize many isoforms and is predicted to have no cross-reactivity to other RIM proteins.
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • RIMS2
      • RAB3IP3
      • RIM2
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~86 kDa observed. Uniprot describes 3 isoforms produced by alternative splicing ranging between ~31 kDa and ~160 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat brain tissue lysate with and without blocking peptide.

      Western Blotting Analysis: 1 μg/mL of this antibody detected RIM 2 in rat brain tissue lysate with and without blocking peptide.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications