MABF284 Anti-RIG1 Antibody, clone 42

MABF284
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, FC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABF284
      DescriptionAnti-RIG1 Antibody, clone 42
      Alternate Names
      • Retinoic acid receptor responder protein 3
      • HRAS-like suppressor 4
      • HRSL4
      • RAR-responsive protein TIG3
      • Retinoid-inducible gene 1 protein
      • Tazarotene-induced gene 3 protein
      Background InformationRIG1 is a cytoplasmically bound enzyme that exhibits phospholipase 1/2 activity and catalyzes the hydrolysis of various important membrane lipids including phosphatidylcholine and phosphatidylethanolamine containing lipids. RIG1 mimics PLA1/2 activities in many tissues and is widely expressed. Recent research has shown that RIG1 also functions as a cytoplasmic pattern receptor that detects viral RNA and acts as a cellular sensor for viral infection, which in turn can activate the proinflammatory response and the production of type-1 interferons against the infection.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-RIG1 Antibody, clone 42 is validated for use in Western Blotting and Flow Cytometry for the detection of RIG1.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 0.25 µg of this antibody from a representative lot detected RIG1 in 1X10E6 THP-1 cells.
      Biological Information
      ImmunogenRecombinant protein corresponding to human RIG1.
      Clone42
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RARRES3
      • RIG1
      • TIG3
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~17 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in THP-1 cell lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected RIG1 in 10 µg of THP-1 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications