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MAB5346 | Anti-RAR alpha Antibody, clone 76

MAB5346
50 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R WB, IHC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB5346
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-RAR alpha Antibody, clone 76
      Alternate Names
      • RARalpha
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA, 50% glycerol.
      Applications
      ApplicationAnti-RAR alpha Antibody, clone 763 is a Mouse Monoclonal Antibody for detection of Retinoic Acid Receptor also known as RAR alpha & has been validated in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern blotting

      Immunohistochemistry

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenPeptide from the N-terminus of human Retinoic Acid Receptor, alpha isotype.
      Clone763
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReacts with Retinoic Acid Receptor, alpha isotype. By Western blot MAB5346 recognizes a ~48 kDa band in rat brain hippocampal homogenate.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RARA
      • RAR-alpha
      • NR1B1
      • RAR
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P10276 # This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression.
      SIZE: 462 amino acids; 50771 Da
      SUBUNIT: Interacts with CDK7 (By similarity). Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NOCA7 in a ligand- inducible manner.
      SUBCELLULAR LOCATION: Nucleus.
      DOMAIN: SwissProt: P10276 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
      PTM: Phosphorylated. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is crucial for transcriptional activity (By similarity).
      DISEASE:SwissProt: P10276 # Chromosomal aberrations involving RARA may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with ZBTB16/PLZF; translocation t(15;17)(q21;q21) with PML; translocation t(5;17)(q32;q11) with NPM.
      SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-RETINOIC ACID RECEPTOR, a ISOTYPE MONOCLONAL ANTIBODY - 2187335 2187335
      MOUSE ANTI-RETINOIC ACID RECEPTOR, a ISOTYPE MONOCLONAL ANTIBODY - 2293684 2293684
      MOUSE ANTI-RETINOIC ACID RECEPTOR, α ISOTYPE -2605589 2605589
      MOUSE ANTI-RETINOIC ACID RECEPTOR,  ISOTYPE -2799105 2799105

      References

      Reference overviewPub Med ID
      Epidermal growth factor receptor (EGFR) is overexpressed in high-grade dysplasia and adenocarcinoma of the esophagus and may represent a biomarker of histological progression in Barrett's esophagus (BE).
      Cronin, J; McAdam, E; Danikas, A; Tselepis, C; Griffiths, P; Baxter, J; Thomas, L; Manson, J; Jenkins, G
      The American journal of gastroenterology 106 46-56 2011

      Show Abstract
      21157443 21157443
      All-trans-retinoic acid stimulates translation and induces spine formation in hippocampal neurons through a membrane-associated RARalpha.
      Chen, N; Napoli, JL
      FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22 236-45 2008

      Show Abstract
      17712061 17712061
      Retinoic acid-gated sequence-specific translational control by RARalpha.
      Poon, Michael M and Chen, Lu
      Proc. Natl. Acad. Sci. U.S.A., 105: 20303-8 (2008) 2008

      Show Abstract
      19073915 19073915
      The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation.
      Chen, N; Onisko, B; Napoli, JL
      The Journal of biological chemistry 283 20841-7 2008

      Show Abstract
      18495661 18495661

      Data Sheet

      Title
      Anti-Retinoic Acid Receptor, alpha, clone 763 - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies