A part of MilliporeSigma

AB10418 | Anti-Puma BH3 domain Antibody

AB10418
100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M WB Rb Purified Polyclonal Antibody
      Description
      Catalogue NumberAB10418
      DescriptionAnti-Puma BH3 domain Antibody
      Alternate Names
      • BCL2 binding component 3
      • Bcl-2 binding component 3
      • p53 up-regulated modulator of apoptosis
      Background InformationPUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis
      References
      Product Information
      FormatPurified
      Control
      • Western Blot : Mouse brain lysate
      PresentationPurified in PBS with 0.09% NaN3.
      Applications
      ApplicationAnti-Puma BH3 domain Antibody is an antibody against Puma BH3 domain for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenThis antibody was developed against a synthetic peptide selected from the C-terminal region of human Puma.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThe antibody reacts with the 21 kDa Puma BH3 domain protein.
      Species Reactivity
      • Mouse
      Species Reactivity NoteReacts with mouse. Other species have not been tested.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • JFY-1
      • JFY1
      • PUMA
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Essential mediator of p53-dependent and p53-independent apoptosis.
      SUBUNIT STRUCTURE: Interacts with MCL1 and BCL2A1 By similarity. Interacts with BCL2 and BCL2L1/BCL-XL.
      SUBCELLULAR LOCATION: Mitochondrion. Note= Localized to the mitochondria in order to induce cytochrome c release.
      TISSUE SPECIFICTY: Ubiquitously expressed.
      INDUCTION: By DNA damage, glucocorticoid treatment, growth factor deprivation and p53.
      SEQUENCE SIMILARITIES: Belongs to the Bcl-2 family.
      Molecular Weight21 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceWestern Blot Analysis: 1:250 dilution of this antibody detected Puma BH3 domain on mouse brain lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at 2-8°C for 6 months from date of receipt. For long term storage, store at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications