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AB5860-200UL | Anti-Potassium Channel TREK-1 Antibody

200 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberAB5860-200UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Potassium Channel TREK-1 Antibody
      Alternate Names
      • Twik-Related K+ Channel 1
      • Kcnk2
      Product Information
      FormatAffinity Purified
      • CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen. The stock solution of the antigen can be made up using 100 μL of sterile distilled water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
      PresentationLyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min.)
      ApplicationDetect Potassium Channel TREK-1 using this Anti-Potassium Channel TREK-1 Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:200 using ECL on rat brain membranes.

      Dilutions should be made using a carrier protein such as BSA (1-3%)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding amino acids 8-28 of human TREK-1 (Accession numbers AAF89743, AAD47569).
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityRecognizes TREK-1 (Twik-Related K+ Channel 1, Kcnk2). The epitope does not share homology with any other known proteins.
      Species Reactivity
      • Human
      • Rat
      Species Reactivity Note It is expected that the antibody will also react with mouse due to sequence homology (17/18). Other species have not been tested.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • KCNK2
      • hTREK-1e
      • MGC126742
      • hTREK-1c
      • TREK
      • TPKC1
      • MGC126744
      • TREK1
      • TREK-1
      • K2p2.1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O95069 # Outward rectifying potassium channel.
      SIZE: 426 amino acids; 47093 Da
      SUBUNIT: Homodimer (Potential).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
      SIMILARITY: SwissProt: O95069 ## Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
      MISCELLANEOUS: Activated by volatile general anesthetics such as chloroform, halothane and isoflurane.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information