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ABS89 | Anti-Plk3 Antibody

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABS89
      DescriptionAnti-Plk3 Antibody
      Alternate Names
      • Serine/threonine-protein kinase PLK3
      • cytokine-inducible serine/threonine-protein kinase
      • FGF-inducible kinase
      • Polo-like kinase 3
      • PLK-3
      • proliferation-related kinase
      Background InformationPlk3 is an NF-κB-regulated kinase that mediates p53-dependent and -independent pro-apoptotic responses to elevated levels of superoxide. It acts as a key regulator of the cell cycle through signaling networks that pertain to centrosome maturation and separation, mitotic entry, chromosome segregation, mitotic exit, and cytokinesis to name a few of several related cellular functions. It serves as an essential component in the hypoxia signaling pathway, demonstrates tumor-suppressing activity, and is suggested to play a role in angiogenesis in PLK3-null mice. Additionally, Plk3 is demonstrated to mediate the cell cycle through its influence on Cdc25 phosphatase function.
      Product Information
      FormatAffinity Purified
      • Human placenta tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationThis Anti-Plk3 Antibody is validated for use in WB for the detection of Plk3.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Plk3.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.
      Gene Symbol
      • PLK3
      • CNK
      • FNK
      • PRK
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Serine/threonine protein kinase involved in regulating M phase functions during the cell cycle. May also be part of the signaling network controlling cellular adhesion. In vitro, is able to phosphorylate CDC25C and casein.

      CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

      SUBUNIT STRUCTURE: Binds to the calcium/integrin-binding protein (CIB). This interaction probably occurs via the POLO-box domain.

      SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
      Molecular Weight~72 kDa observed.
      An uncharacterized band may be seen at a molecular weight of ~35 kDa in some cell lysates.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in Human placenta tissue lysate.

      Western Blot Analysis: A 1:1,000 dilution of this antibody detected Plk3 in human placenta tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information