A part of MilliporeSigma

MAB10424 | Anti-Plexin B3 Antibody, clone 17H10.1

100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
Request Pricing
Limited AvailabilityLimited Availability
Limited Quantities Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers


      Contact Customer Service

      Click To Print This Page


      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R IHC M Purified Monoclonal Antibody
      Catalogue NumberMAB10424
      DescriptionAnti-Plexin B3 Antibody, clone 17H10.1
      Alternate Names
      • plexin B3
      • plexin-B3
      • plexin 6
      Background InformationPlexin-B3 is a member of the plexin-B family of semaphorin receptors. The plexin-B family of receptors may be especially important in axonal guidance during nervous system development. Plexin-B3 is thought to play an intricate and non-redundant role in this development. It is a specific receptor for Semaphorin-5A (Sema5A), whose activation by Sema5A mediates functional responses in Plexin-B3-expressing cells (either fibroblasts, epithelial and primary endothelial cells). Recently, Plexin-B3 has been described as a potent stimulator of neurite outgrowth, making it an intriguing research target for traits related to human brain development and cerebral connectivity.
      Product Information
      • Normal rat brain tissue
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-Plexin B3 Antibody, clone 17H10.1 is an antibody against Plexin B3 for use in IH.
      Key Applications
      • Immunohistochemistry
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Plexin-B3.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Rat
      Species Reactivity NoteDemonstrated to react with rat. Expected to react with human based on immunogen design.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
      Gene Symbol
      • PLXN6
      • PLEXB3
      • PLEXR
      • PLXNB3
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: Receptor for SEMA5A. Plays a role in axon guidance, invasive growth and cell migration.


      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein

      TISSUE SPECIFICTY: Detected at very low levels in several fetal tissues.

      SEQUENCE SIMLARITIES: Belongs to the plexin family.

      Contains 4 IPT/TIG domains.

      Contains 1 Sema domain.

      SEQUENCE CAUTION: The sequence BAA86520.1 differs from that shown. Reason: Erroneous initiation.
      Molecular Weight 206 kDa calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in normal rat brain tissue.

      Immunohistochemistry Analysis: 1:50 dilution of this antibody detected Plexin B3 in normal rat brain tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information